肿瘤消退预测黑色素瘤患者对干扰素治疗的更好反应:一项回顾性单中心研究。

IF 1.5 4区 医学 Q3 DERMATOLOGY Melanoma Research Pub Date : 2024-02-01 Epub Date: 2023-11-13 DOI:10.1097/CMR.0000000000000935
Noémi E Mezőlaki, Eszter Baltás, Henriette L Ócsai, Anita Varga, Irma Korom, Erika Varga, István B Németh, Erika G Kis, János Varga, Ádám Kocsis, Rolland Gyulai, Mátyás Bukva, Lajos Kemény, Judit Oláh
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引用次数: 0

摘要

基于IFN在宿主免疫反应中的作用,我们假设回归可能会影响辅助IFN治疗的有效性。我们的目的是研究退化和溃疡作为干扰素- α (IFN)治疗黑色素瘤患者的预后因素。我们回顾性随访了357例ifn治疗的黑色素瘤患者,根据溃疡和消退的存在调查无进展生存期(PFS)和总生存期(OS)。进行Kaplan-Meier分析,并使用Cox回归分析关联危险因素。Cox回归的生存函数根据原发肿瘤的Breslow厚度(T1-T4)来衡量回归和溃疡对PFS和OS的影响。回归与PFS (P = 0.0018, HR = 0.352)和OS (P = 0.0112, HR = 0.380)呈显著正相关,溃疡呈负相关(PFS: P = 0.0001, HR = 2.629;Os: p = 0.0001, hr = 2.388)。它们独立地影响生存。最有利的结果是在退化/非溃疡组,而最差的是在非退化/溃疡组。在危险因素中,布雷斯洛厚度是最显著的预测因子。尽管在较厚的原发病变中,消退的效果更有利,但与brreslow厚度无关。我们的研究结果表明,对于ifn治疗的黑色素瘤患者,退化与更有利的结果相关,而溃疡则呈反比关系。需要进一步的研究来分析与创新免疫检查点抑制剂相关的回归的生存获益。
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Tumour regression predicts better response to interferon therapy in melanoma patients: a retrospective single centre study.

We hypothesise that regression may have an impact on the effectiveness of adjuvant IFN therapy, based on its role in the host immune response. Our purpose is to investigate regression and ulceration as prognostic factors in case of interferon-alpha (IFN)-treated melanoma patients. We followed 357 IFN-treated melanoma patients retrospectively, investigating progression-free survival (PFS) and overall survival (OS) depending on the presence of ulceration and regression. A Kaplan-Meier analysis was performed, and we used a Cox regression analysis to relate risk factors. The survival function of the Cox regression was used to measure the effect of regression and ulceration on PFS and OS depending on the Breslow thickness (T1-T4) of the primary tumour. Regression was significantly positively related to PFS ( P  = 0.0018, HR = 0.352) and OS ( P  = 0.0112, HR = 0.380), while ulceration showed a negative effect (PFS: P  = 0.0001, HR = 2.629; OS: P  = 0.0003, HR = 2.388). They influence survival independently. The most favourable outcome was measured in the regressed/non-ulcerated group, whereas the worse was in the non-regressed/ulcerated one. Of risk factors, Breslow thickness is the most significant predictor. The efficacy of regression is regardless of Breslow thickness, though the more favourable the impact of regression was in the thicker primary lesions. Our results indicate that regression is associated with a more favourable outcome for IFN-treated melanoma patients, whereas ulceration shows an inverse relation. Further studies are needed to analyse the survival benefit of regression in relation to innovative immune checkpoint inhibitors.

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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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