Wen-Rui Li , Jia-Ying Zhao , Mi Li , Xiao-Jing Wang , Guo-Zhu Su , Hai-Qiang Wang , Li Li , Guan-Hua Du , Ru-Bing Wang , Shuang-Gang Ma
{"title":"山菖蒲叶、枝中佛手柑烷型倍半萜及其抗炎活性","authors":"Wen-Rui Li , Jia-Ying Zhao , Mi Li , Xiao-Jing Wang , Guo-Zhu Su , Hai-Qiang Wang , Li Li , Guan-Hua Du , Ru-Bing Wang , Shuang-Gang Ma","doi":"10.1016/j.phytochem.2023.113617","DOIUrl":null,"url":null,"abstract":"<div><p><span>Eight undescribed β-bergamotene-type sesquiterpene oliganins A-H (</span><strong>1–8</strong>) and one known α-bergamotene-type sesquiterpene (<strong>9</strong>) were isolated from the leaves and twigs of <span><em>Illicium</em><em> oligandrum</em></span> Merr. & Chun. The structures of compounds <strong>1</strong>–<strong>8</strong><span><span><span> were elucidated by extensive spectroscopic data, and the </span>absolute configurations were determined by using a modified Mosher's method and electronic </span>circular dichroism<span> calculations. The isolates were further evaluated in terms of their anti-inflammatory potential on nitric oxide (NO) generation in lipopolysaccharide-stimulated RAW264.7 and BV2 cells. Compounds </span></span><strong>2</strong> and <strong>8</strong> exhibited potent inhibitory effects on the production of NO with IC<sub>50</sub><span> values ranging from 21.65 to 49.28 μM, which were greater than or comparable to those of dexamethasone (positive control).</span></p></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Bergamotane-type sesquiterpenes from the leaves and twigs of Illicium oligandrum and their anti-inflammatory activities\",\"authors\":\"Wen-Rui Li , Jia-Ying Zhao , Mi Li , Xiao-Jing Wang , Guo-Zhu Su , Hai-Qiang Wang , Li Li , Guan-Hua Du , Ru-Bing Wang , Shuang-Gang Ma\",\"doi\":\"10.1016/j.phytochem.2023.113617\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Eight undescribed β-bergamotene-type sesquiterpene oliganins A-H (</span><strong>1–8</strong>) and one known α-bergamotene-type sesquiterpene (<strong>9</strong>) were isolated from the leaves and twigs of <span><em>Illicium</em><em> oligandrum</em></span> Merr. & Chun. The structures of compounds <strong>1</strong>–<strong>8</strong><span><span><span> were elucidated by extensive spectroscopic data, and the </span>absolute configurations were determined by using a modified Mosher's method and electronic </span>circular dichroism<span> calculations. The isolates were further evaluated in terms of their anti-inflammatory potential on nitric oxide (NO) generation in lipopolysaccharide-stimulated RAW264.7 and BV2 cells. Compounds </span></span><strong>2</strong> and <strong>8</strong> exhibited potent inhibitory effects on the production of NO with IC<sub>50</sub><span> values ranging from 21.65 to 49.28 μM, which were greater than or comparable to those of dexamethasone (positive control).</span></p></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2023-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S003194222300033X\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S003194222300033X","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Bergamotane-type sesquiterpenes from the leaves and twigs of Illicium oligandrum and their anti-inflammatory activities
Eight undescribed β-bergamotene-type sesquiterpene oliganins A-H (1–8) and one known α-bergamotene-type sesquiterpene (9) were isolated from the leaves and twigs of Illicium oligandrum Merr. & Chun. The structures of compounds 1–8 were elucidated by extensive spectroscopic data, and the absolute configurations were determined by using a modified Mosher's method and electronic circular dichroism calculations. The isolates were further evaluated in terms of their anti-inflammatory potential on nitric oxide (NO) generation in lipopolysaccharide-stimulated RAW264.7 and BV2 cells. Compounds 2 and 8 exhibited potent inhibitory effects on the production of NO with IC50 values ranging from 21.65 to 49.28 μM, which were greater than or comparable to those of dexamethasone (positive control).
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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