在日本大阪大都市区的一个中心,冠状病毒病(COVID-19)大流行期间中枢性性早熟的频率增加。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.1297/cpe.2022-0008
Kazuki Matsubara, Shinji Higuchi, Yoh Watanabe, Kana Kitayama, Yuki Yamada, Tohru Yorifuji
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引用次数: 2

摘要

由于已知环境因素会影响青春期的时间,在冠状病毒病(COVID-19)大流行期间的自我隔离可能会影响中枢性性早熟(CPP)的发病率。本研究旨在评估日本大阪大都市区单个中心的COVID-19大流行期间CPP的频率。回顾性分析日本首次宣布COVID-19紧急状态前后我院CPP年度发生频率。我们进行了中断时间序列分析,以调查2016年至2021年我院CPP患者的频率。在宣布紧急状态之前和之后,CPP患者的频率显著增加,无论是总体上还是女性中。然而,雄性的数量并没有显著增加。在紧急状态前后诊断的患者的临床、生理和内分泌特征没有显著差异。总体而言,在2019冠状病毒病大流行期间,在日本大阪大都市区的一个中心,CPP的频率显着增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Increased frequency of central precocious puberty during the coronavirus disease (COVID-19) pandemic at a single center in the Osaka Metropolitan Area of Japan.

As environmental factors are known to affect the timing of puberty, self-isolation during the coronavirus disease (COVID-19) pandemic may affect the incidence of central precocious puberty (CPP). This study aimed to evaluate the frequency of CPP during the COVID-19 pandemic at a single center in the Osaka metropolitan area of Japan. We retrospectively analyzed the annual frequency of CPP occurrence before and after the first declaration of COVID-19 state of emergency in Japan at our hospital. We performed an interrupted time-series analysis to investigate the frequency of patients with CPP at our hospital from 2016 to 2021. There was a significant increase in the frequency of patients with CPP before and after the state of emergency declaration, both overall and among females. However, there was no significant increase in the number of males. There were no significant differences in the clinical, auxological, and endocrinological features between those diagnosed before and after the state of emergency. Overall, the frequency of CPP significantly increased during the COVID-19 pandemic at a single center in the Osaka metropolitan area of Japan.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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