{"title":"纳米二氧化钛和消毒剂对颌面部有机硅的抗菌作用。","authors":"Pinar Cevik DDS, PhD , Gulcin Akca MD, PhD , Neset Volkan Asar DDS, PhD , Emine Avci MD , Sudarat Kiat-amnuay DDS, MS , Burak Yilmaz DDS, PhD","doi":"10.1016/j.prosdent.2023.03.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Statement of problem</h3><div><span><span><span>Deficient hygiene of maxillofacial prostheses can be a source of infection, and various </span>disinfectants, including nano-oxides, have been suggested for the disinfection of silicone prostheses. While maxillofacial </span>silicones involving nano-oxides at different sizes and concentrations have been evaluated in terms of their mechanical and physical properties, reports are lacking on the antimicrobial effect of nano titanium dioxide (TiO</span><sub>2</sub><span>) incorporated into maxillofacial silicones contaminated by different biofilms.</span></div></div><div><h3>Purpose</h3><div><span>The purpose of this in vitro study was to evaluate the antimicrobial effects of 6 different disinfectants and nano TiO</span><sub>2</sub> incorporation into maxillofacial silicone contaminated with <span><span>Staphylococcus aureus</span><em>, Escherichia coli</em></span>, and <span><em>Candida albicans</em></span> biofilms.</div></div><div><h3>Material and methods</h3><div>A total of 258 silicone specimens (129 pure silicones and 129 nano TiO<sub>2</sub>-incorporated silicones) were fabricated. Specimens in each silicone group (with or without nano TiO<sub>2</sub><span>) were divided into 7 disinfectant groups (control, 0.2% chlorhexidine gluconate<span><span>, 4% chlorhexidine gluconate, 1% sodium hypochlorite, neutral soap, 100% white </span>vinegar, and effervescent) in each biofilm group. Contaminated specimens were disinfected, and the suspension of each specimen was incubated at 37 °C for 24 hours. Proliferated colonies were recorded in colony-forming units per mL (CFU/mL). The differences in microbial levels among specimens were evaluated to test the effect of the type of silicone and the disinfectant (α=.05).</span></span></div></div><div><h3>Results</h3><div>Significant difference was found among disinfectants regardless of the silicone type (<em>P</em><.05). Nano TiO<sub>2</sub> incorporation showed an antimicrobial effect on <em>S aureus</em>, <em>E coli</em>, and <em>C albicans</em> biofilms. Nano TiO<sub>2</sub> incorporated silicone cleaned with 4% chlorhexidine gluconate had statistically less <em>C albicans</em><span> than pure silicone. Using white vinegar or 4% chlorhexidine gluconate led to no </span><em>E coli</em> on either silicone. Nano TiO<sub>2</sub> incorporated silicone cleaned with effervescent had fewer <em>S aureus</em> or <em>C albicans</em> biofilms.</div></div><div><h3>Conclusions</h3><div>The tested disinfectants and nano TiO<sub>2</sub> incorporation into silicone were effective against most of the microorganisms used in this study.</div></div>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":"133 2","pages":"Pages 608-614"},"PeriodicalIF":4.3000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial effects of nano titanium dioxide and disinfectants on maxillofacial silicones\",\"authors\":\"Pinar Cevik DDS, PhD , Gulcin Akca MD, PhD , Neset Volkan Asar DDS, PhD , Emine Avci MD , Sudarat Kiat-amnuay DDS, MS , Burak Yilmaz DDS, PhD\",\"doi\":\"10.1016/j.prosdent.2023.03.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Statement of problem</h3><div><span><span><span>Deficient hygiene of maxillofacial prostheses can be a source of infection, and various </span>disinfectants, including nano-oxides, have been suggested for the disinfection of silicone prostheses. While maxillofacial </span>silicones involving nano-oxides at different sizes and concentrations have been evaluated in terms of their mechanical and physical properties, reports are lacking on the antimicrobial effect of nano titanium dioxide (TiO</span><sub>2</sub><span>) incorporated into maxillofacial silicones contaminated by different biofilms.</span></div></div><div><h3>Purpose</h3><div><span>The purpose of this in vitro study was to evaluate the antimicrobial effects of 6 different disinfectants and nano TiO</span><sub>2</sub> incorporation into maxillofacial silicone contaminated with <span><span>Staphylococcus aureus</span><em>, Escherichia coli</em></span>, and <span><em>Candida albicans</em></span> biofilms.</div></div><div><h3>Material and methods</h3><div>A total of 258 silicone specimens (129 pure silicones and 129 nano TiO<sub>2</sub>-incorporated silicones) were fabricated. Specimens in each silicone group (with or without nano TiO<sub>2</sub><span>) were divided into 7 disinfectant groups (control, 0.2% chlorhexidine gluconate<span><span>, 4% chlorhexidine gluconate, 1% sodium hypochlorite, neutral soap, 100% white </span>vinegar, and effervescent) in each biofilm group. Contaminated specimens were disinfected, and the suspension of each specimen was incubated at 37 °C for 24 hours. Proliferated colonies were recorded in colony-forming units per mL (CFU/mL). The differences in microbial levels among specimens were evaluated to test the effect of the type of silicone and the disinfectant (α=.05).</span></span></div></div><div><h3>Results</h3><div>Significant difference was found among disinfectants regardless of the silicone type (<em>P</em><.05). Nano TiO<sub>2</sub> incorporation showed an antimicrobial effect on <em>S aureus</em>, <em>E coli</em>, and <em>C albicans</em> biofilms. Nano TiO<sub>2</sub> incorporated silicone cleaned with 4% chlorhexidine gluconate had statistically less <em>C albicans</em><span> than pure silicone. Using white vinegar or 4% chlorhexidine gluconate led to no </span><em>E coli</em> on either silicone. Nano TiO<sub>2</sub> incorporated silicone cleaned with effervescent had fewer <em>S aureus</em> or <em>C albicans</em> biofilms.</div></div><div><h3>Conclusions</h3><div>The tested disinfectants and nano TiO<sub>2</sub> incorporation into silicone were effective against most of the microorganisms used in this study.</div></div>\",\"PeriodicalId\":16866,\"journal\":{\"name\":\"Journal of Prosthetic Dentistry\",\"volume\":\"133 2\",\"pages\":\"Pages 608-614\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Prosthetic Dentistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S002239132300135X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Prosthetic Dentistry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002239132300135X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Antimicrobial effects of nano titanium dioxide and disinfectants on maxillofacial silicones
Statement of problem
Deficient hygiene of maxillofacial prostheses can be a source of infection, and various disinfectants, including nano-oxides, have been suggested for the disinfection of silicone prostheses. While maxillofacial silicones involving nano-oxides at different sizes and concentrations have been evaluated in terms of their mechanical and physical properties, reports are lacking on the antimicrobial effect of nano titanium dioxide (TiO2) incorporated into maxillofacial silicones contaminated by different biofilms.
Purpose
The purpose of this in vitro study was to evaluate the antimicrobial effects of 6 different disinfectants and nano TiO2 incorporation into maxillofacial silicone contaminated with Staphylococcus aureus, Escherichia coli, and Candida albicans biofilms.
Material and methods
A total of 258 silicone specimens (129 pure silicones and 129 nano TiO2-incorporated silicones) were fabricated. Specimens in each silicone group (with or without nano TiO2) were divided into 7 disinfectant groups (control, 0.2% chlorhexidine gluconate, 4% chlorhexidine gluconate, 1% sodium hypochlorite, neutral soap, 100% white vinegar, and effervescent) in each biofilm group. Contaminated specimens were disinfected, and the suspension of each specimen was incubated at 37 °C for 24 hours. Proliferated colonies were recorded in colony-forming units per mL (CFU/mL). The differences in microbial levels among specimens were evaluated to test the effect of the type of silicone and the disinfectant (α=.05).
Results
Significant difference was found among disinfectants regardless of the silicone type (P<.05). Nano TiO2 incorporation showed an antimicrobial effect on S aureus, E coli, and C albicans biofilms. Nano TiO2 incorporated silicone cleaned with 4% chlorhexidine gluconate had statistically less C albicans than pure silicone. Using white vinegar or 4% chlorhexidine gluconate led to no E coli on either silicone. Nano TiO2 incorporated silicone cleaned with effervescent had fewer S aureus or C albicans biofilms.
Conclusions
The tested disinfectants and nano TiO2 incorporation into silicone were effective against most of the microorganisms used in this study.
期刊介绍：
The Journal of Prosthetic Dentistry is the leading professional journal devoted exclusively to prosthetic and restorative dentistry. The Journal is the official publication for 24 leading U.S. international prosthodontic organizations. The monthly publication features timely, original peer-reviewed articles on the newest techniques, dental materials, and research findings. The Journal serves prosthodontists and dentists in advanced practice, and features color photos that illustrate many step-by-step procedures. The Journal of Prosthetic Dentistry is included in Index Medicus and CINAHL.
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