埃塞俄比亚西北部综合专科医院双相情感障碍患者功能结局及其决定因素的评估:一项多中心医院研究

IF 3.6 3区 医学 Q1 PSYCHIATRY Annals of General Psychiatry Pub Date : 2023-04-06 DOI:10.1186/s12991-023-00444-3
Melak Erara Mengistu, Simegnew Handebo Berassa, Abebe Tarekegn Kassaw, Ephrem Mebratu Dagnew, Gizework Alemnew Mekonen, Mequanent Kassa Birarra
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引用次数: 1

摘要

简介:双相情感障碍是一种严重的慢性精神疾病,可能会持续一生。虽然它是导致大量患者残疾和损伤的主要原因,但在埃塞俄比亚尚未对功能结果的水平进行研究。因此,本研究旨在评估埃塞俄比亚西北部双相情感障碍患者的功能结局水平和相关因素。方法:对2021年4月至6月在埃塞俄比亚西北部精神病诊所就诊的双相情感障碍患者进行基于医院的横断面研究。采用系统随机抽样的方法获得调查对象。进行了描述性和推断性统计。数据输入EpiData 4.6.02版本,导出到SPSS 22版本进行分析。采用双变量和多变量二元logistic回归分析确定与功能结局水平相关的因素,p值分析结果:在共接触的423名研究参与者中,只有411人完成了问卷调查,应答率为97.2%。功能预后的中位(IQR)水平为6(0-22),40%的研究对象受损。休闲时间是最正常的功能域(92.2%),而认知(43.5%)和职业(41.6%)是最受损的功能域。失业(AOR (95%CI) = 3.9(1.46 ~ 10.49)、肥胖(AOR (95%CI) = 6.5(1.22 ~ 34.58)、抑郁和躁期情绪(AOR (95%CI)分别= 5.2(2.84 ~ 9.35)和(AOR (95%CI) = 7.8(3.31 ~ 18.34)、药物依从性(AOR (95%CI) = 3.2(1.71 ~ 6.05)、复发1次或≥2次(AOR (95%CI) = 2.2(1.25 ~ 3.98)和(AOR (95%CI) = 8.3(2.73 ~ 25.30)是与功能障碍水平显著相关的重要预测变量。结论:功能结局水平的中位数在可接受范围内;然而,相当数量的双相患者功能受损。此外,患者在认知和职业功能领域仍然需要不受限制的干预。社会人口统计学、临床、药物和社会心理变量与功能结局显著相关。需要对双相患者进行随访和管理,以改善其功能结果,所有利益相关者都应参与,以达到推荐的水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Assessments of functional outcomes and its determinants among bipolar disorder patients in Northwest Ethiopia comprehensive specialized hospitals: a multicenter hospital-based study.

Introduction: Bipolar disorder is a severe and chronic mental illness that could continue for a lifetime. Although it is a leading cause of disability and impairments for significant numbers of patients, the levels of functional outcomes have not been studied in Ethiopia. Therefore, this study aimed to assess the functional outcome levels and associated factors among bipolar disorder patients in Northwest Ethiopia.

Method: Hospital-based cross-sectional study was employed among bipolar disorder patients attending psychiatric clinics, in Northwest Ethiopia, from April to June 2021. Systematic random sampling was used to get respondents. Descriptive and inferential statistics were done. Data were entered into EpiData version 4.6.02 and exported to SPSS Version 22 for analysis. Bivariable and multivariable binary logistic regression analysis was used to identify the factors associated with functional outcome levels, and p value < 0.05 was considered significant with 95% CI.

Result: Of the total 423 study participants approached, only 411 completed the questionnaire, with a response rate of 97.2%. The median (IQR) level of functional outcome was 6 (0-22) and 40% of the study subjects were impaired. Leisure time was the most normal functioning domain (92.2%), whereas cognitive (43.5%) and occupational (41.6%) domains were the most impaired domains. Unemployment (AOR (95%CI) = 3.9 (1.46-10.49), obesity (AOR (95% CI) = 6.5 (1.22-34.58), depressed and manic mood phases (AOR (95%CI) = 5.2 (2.84-9.35) and (AOR (95%CI) = 7.8 (3.31-18.34) respectively, medication non-adherence (AOR (95% CI) = 3.2 (1.71-6.05), and relapsed once or ≥ twice (AOR (95%CI) = 2.2 (1.25-3.98) and (AOR (95%CI) = 8.3 (2.73-25.30), respectively, were some of the important predictor variables that were significantly associated to the functional impairments levels.

Conclusion: The median of functional outcomes levels was found in an acceptable range; however, significant numbers of bipolar patients were functionally impaired. Moreover, patients still need unrestricted interventions in the cognitive and occupational functional domains. Socio-demographic, clinical, medication, and psychosocial variables were significantly associated with functional outcomes. Bipolar patients need to be followed and managed to improve their functional outcome and all stakeholders should be involved to achieve the recommended levels.

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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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