肥大细胞与肿瘤免疫治疗的耐药性

IF 2.9 4区医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2023-04-11 DOI:10.1007/s00005-023-00676-x

Domenico Ribatti

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引用次数: 0

摘要

肥大细胞参与肿瘤生长，其介质在不同的人类癌症中发挥促肿瘤和抗肿瘤作用。肿瘤微环境中存在的免疫抑制途径的确定，为在这种情况下促进炎症和/或先天免疫激活提供了有针对性的治疗策略。肥大细胞可以促进免疫抑制肿瘤微环境，也可能增强抗肿瘤反应。本文就肥大细胞在肿瘤免疫治疗耐药中的作用机制作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mast Cells and Resistance to Immunotherapy in Cancer

Mast cells are involved in tumor growth and their mediators exert both pro- and anti-tumorigenic roles in different human cancers. The identification of defined immunosuppressive pathways that are present in the tumor microenvironment has pointed therapeutic strategies that may promote inflammation and/or innate immune activation in this context. Mast cells can contribute to the immune suppressive tumor microenvironment and may also enhance anti-tumor responses. This review article is focused on the analysis of the mechanisms of the role of mast cells in resistance to immunotherapy in cancer.

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来源期刊

Archivum Immunologiae et Therapiae Experimentalis 医学-免疫学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.