碳离子治疗中扫描-被动散射光束的后投影零和收敛arcTAN法确定虚源位置。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.3233/XST-221274
Wan-Bin Meng, Qiang Li, Yan-Cheng Ye, Jia-Ming Wu
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引用次数: 0

摘要

目的:本研究旨在开发和测试一种能够处理扫描-被动散射束模式下不同碳离子能量传递的虚拟源位置的新技术。材料与方法:采用国产大幅面CMOS传感器和Gaf Chromic EBT3薄膜进行虚拟源位置测量。Gaf薄膜被嵌入到一个自行设计的矩形塑料框架中,用于收紧薄膜,并被放置在治疗台上进行空气照射,薄膜垂直于碳离子束在标称源轴距离(SAD)以及SAD的上游和下游。本文研究了5能量水平碳离子束在开机场尺寸下的运动。采用收敛arcTAN (cATAN)方法确定了虚拟源位置,并与反向投影FWHM的线性回归进行了比较。结果:薄膜FWHM测量误差为0.5 mm,在每个假设延伸处α (cATAN)偏差为0.001%。通过在垂直和水平方向上的假设延伸计算出的虚拟源位置的再现性的总体不确定性为0.1%。采用后投影FWHM归零方法计算的虚源位置误差在1.1±0.001以内,p = 0.033。结论:本文提出了一种用收敛arcTAN法处理虚拟源位置的新技术,避免了扫描被动散射碳离子束的人工测量误差。鼓励读者在本研究中使用所提出的cATAN方法来研究基于linac的外部电子束和质子束中的虚拟源位置。
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Determination of virtual source position using back projecting zero and convergent arcTAN method for scanning-passive scatter beam in carbon ion therapy.

Objective: This study aims to develop and test a new technique by using the convergent arcTAN (cATAN) method capable of dealing with the virtual source position delivered by different carbon ion energies from the pattern of scanning-passive scatter beam.

Materials and methods: A homemade large-format CMOS sensor and Gaf Chromic EBT3 films are used for the virtual source position measurement. The Gaf films are embedded in a self-designed rectangular plastic frame to tighten films and set up on a treatment couch for irradiation in air with the film perpendicular to the carbon ion beam at the nominal source-axis-distance (SAD) as well as upstream and downstream from the SAD. The horizontal carbon ion beam with 5 energies at a machine opening field size is carried out in this study. The virtual source position is determined by using the convergent arcTAN (cATAN) method and compared with a linear regression by back projecting FWHM to zero at a distance upstream from the various source-film-distance.

Results: The film FWHM measurement error of 0.5 mm leads to 0.001% deviation of α (cATAN) at every assumed textend. The overall uncertainty for the reproducibility of calculated virtual source position by the assumed textend in the vertical and horizontal directions amounts to 0.1%. The errors of calculated virtual source position by assumed textend with back projecting FWHM to zero methods are within 1.1±0.001, p = 0.033.

Conclusion: We develop a new technique capable of dealing with the virtual source position with a convergent arcTAN method to avoid any manual measurement mistakes in scanning-passive scatter carbon ion beam. The readers are encouraged to conduct the proposed cATAN method in this study to investigate the virtual source position in the Linac-based external electron beams and the proton beams.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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