好警察,坏警察:多胺在宿主免疫和病毒复制中扮演两面角色

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI:10.1016/j.semcdb.2022.12.004
Yazmin E. Cruz-Pulido , Bryan C. Mounce
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引用次数: 0

摘要

病毒依赖宿主细胞获得基因组复制和颗粒组装所需的能量和合成机制。由于病毒对宿主细胞的依赖性,病毒已经进化出多种机制,通过这些机制,它们可以诱导宿主细胞的代谢变化,以适应它们的特定需求。宿主的免疫反应还涉及代谢变化,从而能够对病毒损伤做出反应。多胺是小的普遍表达的聚阳离子,它们的代谢对病毒复制和充分的宿主免疫反应至关重要。这是由于多胺具有多种功能,从浓缩DNA到通过分泌eIF5A来增强含多肽蛋白的翻译。在这里,我们回顾了病毒利用多胺的各种机制,以及免疫细胞利用多胺发挥功能的机制。此外,我们强调了进一步研究宿主病毒界面的潜在途径。
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Good cop, bad cop: Polyamines play both sides in host immunity and viral replication

Viruses rely on host cells for energy and synthesis machinery required for genome replication and particle assembly. Due to the dependence of viruses on host cells, viruses have evolved multiple mechanisms by which they can induce metabolic changes in the host cell to suit their specific requirements. The host immune response also involves metabolic changes to be able to react to viral insult. Polyamines are small ubiquitously expressed polycations, and their metabolism is critical for viral replication and an adequate host immune response. This is due to the variety of functions that polyamines have, ranging from condensing DNA to enhancing the translation of polyproline-containing proteins through the hypusination of eIF5A. Here, we review the diverse mechanisms by which viruses exploit polyamines, as well as the mechanisms by which immune cells utilize polyamines for their functions. Furthermore, we highlight potential avenues for further study of the host-virus interface.

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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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Diverse genetic conflicts mediated by molecular mimicry and computational approaches to detect them Outside Front Cover Editorial Board/Publication Information From the cauldron of conflict: Endogenous gene regulation by piRNA and other modes of adaptation enabled by selfish transposable elements Outside Front Cover
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