Ibrahim Elmakaty, Basel Elsayed, Mohamed Elmarasi, Omar Kujan, Mohammed Imad Malki
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引用次数: 1
摘要
目的:探讨头颈部鳞状细胞癌(HNSSC)患者CC趋化因子受体7 (CCR7)表达的临床病理特征及预后价值。方法:本荟萃分析遵循系统评价和荟萃分析指南的首选报告项目。截至2022年7月2日，检索使用了五个数据库:PubMed, Embase, Scopus, ProQuest和Web of Science。采用流行病学研究量表的方法学标准评价纳入文章的质量，采用Stata软件综合meta分析。结果:我们考虑了615项研究中的13项，其中包括1005例HNSCC患者。CCR7的高表达使晚期、肿瘤大小、转移和复发的合并优势比(OR)分别增加2.82(95%可信区间(CI) 1.84 ~ 4.33)、2.48 (95% CI 1.68 ~ 3.67)、3.57 (95% CI 2.25 ~ 5.05)和3.93 (95% CI 2.03 ~ 7.64)。高CCR7降低了患者的总生存率[风险比2.62 (95% CI 1.59 - 4.32)]。结论:本研究表明，CCR7在HNSCC肿瘤中高表达与较差的临床病理和生存结果显著相关，提示CCR7及其通路可能是HNSCC潜在的治疗策略。
Clinicopathological and prognostic value of chemokine receptor CCR7 expression in head and neck squamous cell carcinoma: a systematic review and meta-analysis.
Objectives: This study aimed to identify the clinicopathological characteristics and prognostic value of CC chemokine receptor 7 (CCR7) expression in patients with head and neck squamous cell carcinoma (HNSSC).
Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in this meta-analysis. Up to the 2nd of July 2022 a search was conducted using five databases: PubMed, Embase, Scopus, ProQuest, and Web of Science. The methodological standards for the epidemiological research scale were used to assess the quality of the included articles, and Stata software was used to synthesize the meta-analysis.
Results: We considered 13 of the 615 studies which included 1005 HNSCC patients. High expression of CCR7 increased the pooled odds ratio (OR) of advanced stage, tumor size, metastasis and recurrence by 2.82 [95% confidence interval (CI) 1.84 to 4.33], 2.48 (95% CI 1.68, to 3.67), 3.57, 95% CI 2.25 to 5.05) and 3.93 (95% CI 2.03 to 7.64), respectively. High CCR7 reduced overall patient survival [hazard ratio 2.62 (95% CI 1.59 to 4.32)].
Conclusion: This study showed that high expression of CCR7 in HNSCC tumors was significantly associated with worse clinicopathological and survival outcomes, suggesting that CCR7 and its pathway could be potential therapeutic strategies for HNSCC.
期刊介绍：
Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches.
Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care.
Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections:
Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results
Article Highlights – an executive summary of the author’s most critical points.
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