术前乳酸脱氢酶与白蛋白比值高是否预示食管癌患者生存率低?

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Annals of Thoracic and Cardiovascular Surgery Pub Date : 2023-10-20 Epub Date: 2023-03-01 DOI:10.5761/atcs.oa.23-00004
Fumiaki Shiratori, Takashi Suzuki, Satoshi Yajima, Yoko Oshima, Tatsuki Nanami, Kimihiko Funahashi, Hideaki Shimada
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摘要

目的:乳酸脱氢酶与白蛋白的比值(LAR)已被报道为各种癌症的潜在预后生物标志物;然而,关于食管癌症的资料报道很少。因此,本研究旨在评估术前LAR对癌症患者预后的意义。方法:本研究纳入了236名癌症食管癌患者(193名男性和43名女性;平均年龄66岁[范围41-83岁]),他们在2008年9月至2020年3月期间接受了治疗性手术。共有107名患者接受了前期手术,129名患者接受新辅助治疗。根据术前LAR,将患者分为两组,高LAR和低LAR,截止值为6.2。通过单因素和多因素分析评估术前LAR的临床病理和预后意义。结果:深部肿瘤患者和新辅助治疗与高LAR显著相关(p结论:高LAR是食管癌症患者预后不良的有用生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Is High Score of Preoperative Lactate Dehydrogenase to Albumin Ratio Predicting Poor Survivals in Esophageal Carcinoma Patients?

Purpose: The lactate dehydrogenase-to-albumin ratio (LAR) has been reported as a potential prognostic biomarker in various cancers; however, only a few pieces of information have been reported on esophageal cancer. Therefore, this study aimed to evaluate the prognostic significance of preoperative LAR in patients with esophageal cancer.

Methods: This study included 236 patients (193 men and 43 women; mean age of 66 years [range, 41-83 years]) with esophageal cancer who underwent curative surgery between September 2008 and March 2020. A total of 107 patients underwent upfront surgery, and 129 patients received neoadjuvant treatment. Patients were assigned into two groups, high and low LAR, based on preoperative LAR using a cutoff value of 6.2. The clinicopathological and prognostic significance of preoperative LAR was evaluated in univariate and multivariate analyses.

Results: Patients with deep tumors and neoadjuvant treatment were significantly associated with high LAR (p <0.05). The high LAR group showed a significantly poorer prognosis than the low LAR group (p <0.01). The multivariate analysis for the overall survival showed that deep tumors, lymph node metastasis, and high LAR were independent poor prognostic factors (p <0.05).

Conclusion: High LAR was a useful poor prognostic biomarker in patients with esophageal cancer.

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来源期刊
Annals of Thoracic and Cardiovascular Surgery
Annals of Thoracic and Cardiovascular Surgery CARDIAC & CARDIOVASCULAR SYSTEMS-SURGERY
CiteScore
2.80
自引率
0.00%
发文量
56
审稿时长
4-8 weeks
期刊介绍: Information not localized
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