植物保护剂对四氧嘧啶型糖尿病大鼠肝脏NAD + +和NADP + +激酶功能的影响

Q3 Biochemistry, Genetics and Molecular Biology Biomeditsinskaya khimiya Pub Date : 2023-04-01 DOI:10.18097/PBMC20236902104

A T Eprintsev, N V Selivanova

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引用次数: 0

摘要

大鼠实验性四氧嘧啶型糖尿病的发生伴随着肝脏NAD +和NADP +依赖性苹果酸酶(ME)活性的升高;NAD + -ME, EC 1.1.1.39和NADP + -ME, 1.1.1.40)与编码这些酶的基因的转录率增加有关。糖尿病大鼠口服菊芋和橄榄水提物，血糖明显降低，所研究基因的转录率下降;肌代谢能活动向正常值下降。因此，菊蓟和橄榄提取物可作为糖尿病标准治疗的添加剂。

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The effect of phytoprotectors on the functioning of liver NAD⁺- and NADP⁺-maliс enzymes in rats with alloxan diabetes.

The development of experimental alloxan diabetes in rats was accompanied by the increase the activity of liver NAD⁺- and NADP⁺-dependent malic enzymes (ME; NAD⁺-ME, EC 1.1.1.39 and NADP⁺-ME, 1.1.1.40) associated with an increase in the rate of transcription of genes encoding these enzymes. Oral administration of aqueous extracts of Jerusalem artichoke and olive to diabetic rats caused a noticeable decrease in blood glucose, a decrease in the rate of transcription of the studied genes; and a decrease in ME activity towards normal values. Thus, extracts of Jerusalem artichoke and olive can be used as additives to the standard therapy of diabetes mellitus.

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).