家族性地中海热和脊椎关节炎患者的双重生物治疗:基于病例的回顾。

IF 1.3 Q4 RHEUMATOLOGY European journal of rheumatology Pub Date : 2023-01-01 DOI:10.5152/EuJRheum.2022.21180
Derya Yıldırım, Rıza Can Kardaş, Burcugul Özkızıltaş, İbrahim Vasi, Hamit Küçük, Mehmet Akif Öztürk, Abdurrahman Tufan
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引用次数: 2

摘要

家族性地中海热和脊柱炎患者通常对常规和生物治疗无效。这些患者的缓解通常需要常规治疗和生物治疗相结合。对于难治性疾病的家族性地中海热和脊柱炎患者,联合使用生物制剂可能是一个有希望的选择。直到最近,关于这种治疗策略的有效性和安全性的证据有限。为了解决这个问题,我们的报告提出了4例家族性地中海热和脊柱炎患者的病例系列,这些患者对标准治疗有耐药性,只有通过双重生物治疗才能缓解。作者还对报道炎症性疾病双重生物治疗的研究进行了文献检索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Dual Biologic Therapy in Patients with Familial Mediterranean Fever and Spondyloarthritis: Case-Based Review.
Patients with familial Mediterranean fever and spondylitis often fail to respond to conventional and biologic therapies. Achieving remission in these patients usually requires conventional and biologic treatment combinations. Combination of biologic agents may be a promising option for patients with familial Mediterranean fever and spondylitis who have refractory disease. Until recently, limited evidence existed regarding the efficacy and safety of this treatment strategy. To address this, our report presented a case series of 4 patients with familial Mediterranean fever and spondylitis who were resistant to standard treatments and in whom remission is achieved only with dual biologic therapy. The authors also conducted a literature search for studies that reported dual biological therapy in inflammatory diseases.
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审稿时长
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