鞘脂代谢及其与心血管、肾脏和代谢性疾病的关系。

IF 0.7 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Archivos de cardiologia de Mexico Pub Date : 2023-01-01 DOI:10.24875/ACM.21000333

Fernando Hernández-Bello, Martha Franco, Óscar Pérez-Méndez, Luis Donis-Maturano, Gabriela Zarco-Olvera, Rocío Bautista-Pérez

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引用次数: 1

摘要

鞘脂(鞘磷脂、糖脂、神经节苷)位于细胞膜、血浆和脂蛋白中。在心血管、肾脏和代谢性疾病患者中，鞘脂及其代谢物(神经酰胺、鞘氨醇和鞘氨醇-1-磷酸)的谱被改变，这些变化可能解释一些细胞反应的改变，如凋亡。此外，鞘氨醇和鞘氨醇-1-磷酸被认为可以预防COVID-19。本文还简要介绍了神经鞘脂及其代谢产物的研究技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sphingolipid metabolism and its relationship with cardiovascular, renal and metabolic diseases.

Sphingolipids (sphingomyelin, glycolipids, gangliosides) are located in cell membranes, plasma, and lipoproteins. In patients with cardiovascular, renal, and metabolic diseases, the profile of sphingolipids and their metabolites (ceramide, sphingosine, and sphingosine-1-phosphate) is modified, and these changes may explain the alterations in some cellular responses such as apoptosis. Furthermore, sphingosine and sphingosine-1-phosphate have been suggested to prevent COVID-19. This review also briefly mentions the techniques that allow us to study sphingolipids and their metabolites.

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