低收入国家心力衰竭的人群流行病学:海地心血管疾病队列。

IF 6.9 2区 医学 Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-02-01 Epub Date: 2022-12-06 DOI:10.1161/CIRCOUTCOMES.122.009093
Justin R Kingery, Nicholas L Roberts, Jean Lookens Pierre, Rodney Sufra, Eliezer Dade, Vanessa Rouzier, Rodolphe Malebranche, Michel Theard, Parag Goyal, Altaf Pirmohamed, Lily D Yan, Myung Hee Lee, Denis Nash, Miranda Metz, Robert N Peck, Monika M Safford, Daniel Fitzgerald, Marie M Deschamps, Jean W Pape, Margaret McNairy
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引用次数: 0

摘要

背景:心血管疾病对生活在中低收入国家的人的影响尤为严重,心力衰竭被认为是主要原因。缺乏对这些环境中HF流行病学特征的基于人群的研究。我们描述了基于人群的海地心血管疾病队列中HF的年龄标准化患病率、生存率、亚型、危险因素和1年死亡率。方法:在海地太子港采用多阶段整群区域随机抽样招募参与者。共有2981人完成了标准化病史和检查、实验室测量和心脏成像。临床HF由Framingham标准定义。Kaplan-Meier和Cox比例风险回归评估了HF和非HF参与者的死亡率;逻辑回归确定了相关因素。结果:在所有参与者中,中位年龄为40岁(四分位间距为27-55岁),58.2%为女性。中位随访时间为15.4个月(四分位间距为9-22)。年龄标准化HF患病率为3.2%(93/2981[95%CI,2.6-3.9])。HF参与者的平均年龄为57岁(四分位间距,45-65),67.7%为女性。HF患病率的首次显著增加发生在30至39岁至40至49岁之间(1.1%对3.7%,P=0.003)。射血分数保持的HF是最常见的HF亚型(71.0%)。年龄(调整比值比,每10年增加1.36[1.12-1.66])、高血压(2.14[1.26-3.66])、肥胖(3.35[95%CI,1.99-5.62])、贫困(2.10[1.18-3.72]),肾功能障碍(5.42[2.94-9.98])与HF有关。一年HF死亡率分别为6.6%和0.8%(危险比,7.7[95%CI,2.9-20.6];P结论:在低收入环境中,HF的年龄标准化患病率高得惊人,比中低收入国家的建模估计高出3.2%-5倍。患有HF的成年人比没有HF的人年轻20岁,1岁时死亡的可能性高出7.7倍。进一步研究低收入和中等收入国家HF的人口负担,可以指导资源分配和制定实用的HF预防和治疗干预措施,最终缩小全球心血管疾病健康差距。注册:URL:https://www.Clinicaltrials:政府;唯一标识符:NCT03892265。
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Population-Based Epidemiology of Heart Failure in a Low-Income Country: The Haiti Cardiovascular Disease Cohort.

Background: Cardiovascular disease disproportionately affects persons living in low- and middle-income countries and heart failure (HF) is thought to be a leading cause. Population-based studies characterizing the epidemiology of HF in these settings are lacking. We describe the age-standardized prevalence, survival, subtypes, risk factors, and 1-year mortality of HF in the population-based Haiti Cardiovascular Disease Cohort.

Methods: Participants were recruited using multistage cluster-area random sampling in Port-au-Prince, Haiti. A total of 2981 completed standardized history and exam, laboratory measures, and cardiac imaging. Clinical HF was defined by Framingham criteria. Kaplan-Meier and Cox proportional hazard regression assessed mortality among participants with and without HF; logistic regression identified associated factors.

Results: Among all participants, the median age was 40 years (interquartile range, 27-55), and 58.2% were female. Median follow-up was 15.4 months (interquartile range, 9-22). The age-standardized HF prevalence was 3.2% (93/2981 [95% CI, 2.6-3.9]). The average age of participants with HF was 57 years (interquartile range, 45-65), and 67.7% were female. The first significant increase in HF prevalence occurred between 30 to 39 and 40 to 49 years (1.1% versus 3.7%, P=0.003). HF with preserved ejection fraction was the most common HF subtype (71.0%). Age (adjusted odds ratio, 1.36 [1.12-1.66] per 10-year increase), hypertension (2.14 [1.26-3.66]), obesity (3.35 [95% CI, 1.99-5.62]), poverty (2.10 [1.18-3.72]), and renal dysfunction (5.42 [2.94-9.98]) were associated with HF. One-year HF mortality was 6.6% versus 0.8% (hazard ratio, 7.7 [95% CI, 2.9-20.6]; P<0.0001).

Conclusions: The age-standardized prevalence of HF in this low-income setting was alarmingly high at 3.2%-5-fold higher than modeling estimates for low- and middle-income countries. Adults with HF were two decades younger and 7.7× more likely to die at 1 year compared with those in the community without HF. Further research characterizing the population burden of HF in low- and middle-income countries can guide resource allocation and development of pragmatic HF prevention and treatment interventions, ultimately reducing global cardiovascular disease health disparities.

Registration: URL: https://www.

Clinicaltrials: gov; Unique identifier: NCT03892265.

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来源期刊
Circulation. Cardiovascular Quality and Outcomes
Circulation. Cardiovascular Quality and Outcomes Medicine-Cardiology and Cardiovascular Medicine
CiteScore
9.80
自引率
2.90%
发文量
357
期刊介绍: Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal, publishes articles related to improving cardiovascular health and health care. Content includes original research, reviews, and case studies relevant to clinical decision-making and healthcare policy. The online-only journal is dedicated to furthering the mission of promoting safe, effective, efficient, equitable, timely, and patient-centered care. Through its articles and contributions, the journal equips you with the knowledge you need to improve clinical care and population health, and allows you to engage in scholarly activities of consequence to the health of the public. Circulation: Cardiovascular Quality and Outcomes considers the following types of articles: Original Research Articles, Data Reports, Methods Papers, Cardiovascular Perspectives, Care Innovations, Novel Statistical Methods, Policy Briefs, Data Visualizations, and Caregiver or Patient Viewpoints.
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