为糖萼的普遍药理靶向奠定了基础。

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2023-01-01 DOI:10.1016/bs.ctm.2023.02.004
Karim Almahayni, Leonhard Möckl
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引用次数: 1

摘要

人体的所有细胞都被一个复杂的糖网所覆盖,这些糖以及与这些糖相连的蛋白质和脂质,统称为糖萼。在过去的几十年里,糖萼参与了一系列健康和疾病的重要细胞过程。因此,它作为一种治疗靶点引起了相当大的兴趣。考虑到它的无所不在和它与细胞生物学各个领域的相关性,糖萼应该是一个多功能的治疗干预平台,然而,糖萼作为治疗靶点的全部潜力尚未展开。这可能是由于糖萼改变目前主要在特定疾病的背景下讨论的事实。在本综述中,我们将注意力从以疾病为中心的糖萼转移到糖萼状态的变化上。此外,我们调查了目前可用的重要糖萼靶向药物,最后讨论了未来的步骤。我们希望这种方法将激发对疾病中糖萼的统一,整体的看法,有助于刺激新的糖萼靶向治疗策略。
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Setting the stage for universal pharmacological targeting of the glycocalyx.

All cells in the human body are covered by a complex meshwork of sugars as well as proteins and lipids to which these sugars are attached, collectively termed the glycocalyx. Over the past few decades, the glycocalyx has been implicated in a range of vital cellular processes in health and disease. Therefore, it has attracted considerable interest as a therapeutic target. Considering its omnipresence and its relevance for various areas of cell biology, the glycocalyx should be a versatile platform for therapeutic intervention, however, the full potential of the glycocalyx as therapeutic target is yet to unfold. This might be attributable to the fact that glycocalyx alterations are currently discussed mainly in the context of specific diseases. In this perspective review, we shift the attention away from a disease-centered view of the glycocalyx, focusing on changes in glycocalyx state. Furthermore, we survey important glycocalyx-targeted drugs currently available and finally discuss future steps. We hope that this approach will inspire a unified, holistic view of the glycocalyx in disease, helping to stimulate novel glycocalyx-targeted therapy strategies.

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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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