用于治疗心血管疾病的载药植入装置。

IF 5 2区 医学 Q1 PHARMACOLOGY & PHARMACY Expert Opinion on Drug Delivery Pub Date : 2023-04-01 DOI:10.1080/17425247.2023.2190580
Masoud Adhami, Niamh K Martin, Ciara Maguire, Aaron J Courtenay, Ryan F Donnelly, Juan Domínguez-Robles, Eneko Larrañeta
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引用次数: 2

摘要

导读:人们普遍认为心血管疾病(cvd)仍然是全球死亡的主要原因。此外,心血管疾病是患者生活质量下降的主要原因,通常是由于其进行性恶化。将药物释放到体内的医疗植入物是一种活性植入物,它不仅仅提供机械支持;它们也有治疗作用。这主要是通过在实施现场控制活性药物成分(API)的释放来实现的。涵盖的领域:在这篇综述中,作者讨论了药物洗脱支架、药物洗脱血管移植物和药物洗脱心脏贴片,目的是提供三种最常见的心脏植入物的广泛概述。专家意见:药物洗脱植入物是传统药物传递的理想选择,因为它们允许准确的药物释放,局部药物传递到目标组织,并最大限度地减少与全身给药相关的不良副作用。尽管仍有挑战需要解决,但不断发展的新技术正在使药物洗脱植入物的制造成为一项有益的治疗努力,并有可能取得更大的进步。
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Drug loaded implantable devices to treat cardiovascular disease.

Introduction: It is widely acknowledged that cardiovascular diseases (CVDs) continue to be the leading cause of death globally. Furthermore, CVDs are the leading cause of diminished quality of life for patients, frequently as a result of their progressive deterioration. Medical implants that release drugs into the body are active implants that do more than just provide mechanical support; they also have a therapeutic role. Primarily, this is achieved through the controlled release of active pharmaceutical ingredients (API) at the implementation site.

Areas covered: In this review, the authors discuss drug-eluting stents, drug-eluting vascular grafts, and drug-eluting cardiac patches with the aim of providing a broad overview of the three most common types of cardiac implant.

Expert opinion: Drug eluting implants are an ideal alternative to traditional drug delivery because they allow for accurate drug release, local drug delivery to the target tissue, and minimize the adverse side effects associated with systemic administration. Despite the fact that there are still challenges that need to be addressed, the ever-evolving new technologies are making the fabrication of drug-eluting implants a rewarding therapeutic endeavor with the possibility for even greater advances.

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来源期刊
CiteScore
11.10
自引率
3.00%
发文量
104
审稿时长
3 months
期刊介绍: Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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