灵芝灵芝对实验性代谢综合征高血糖、血脂异常的影响。

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI:10.1615/IntJMedMushrooms.2023047834
Tetiana S Petryn, Mariia R Nagalievska, Solomon P Wasser, Nataliya O Sybirna
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引用次数: 0

摘要

研究了灵芝热水提取物对果糖诱导代谢综合征大鼠碳水化合物代谢和脂质谱的影响。本研究使用的是近交系白色雄性Wistar大鼠,其代谢综合征是通过饮用10%的果糖溶液而不是饮用水引起的,持续42天。诱导代谢综合征后,以水悬浮液形式(剂量为动物体重的1 g/kg)给药7 d和14 d。葡萄糖浓度测定采用葡萄糖氧化酶法。用比色法测定红细胞中糖化血红蛋白的含量。用酶法测定血浆中甘油三酯、胆固醇、高密度脂蛋白和低密度脂蛋白的浓度。在代谢综合征的动物中,糖基化血红蛋白的含量显著降低,与所研究的悬浮液的施用背景有关。在实验性代谢综合征条件下,与代谢综合征相比,给予菌丝体7天和14天使甘油三酯浓度分别下降17.8%和44.8%,胆固醇浓度分别下降10.7%和21.3%,低密度脂蛋白浓度分别下降14.8%和28.4%,高密度脂蛋白浓度分别增加11.9%和21.5%。结果表明,灵芝粉末状菌丝体悬浮液对小鼠碳水化合物和脂质代谢的改善作用与给药时间成正比。
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Effect of the Lingzi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on Hyperglycemia and Dyslipidemia with Experimental Metabolic Syndrome.

The effect of Ganoderma lucidum hot water extract of submerged cultivated mycelium suspensia on carbohydrate metabolism and lipid profile during fructose-induced metabolic syndrome in rats was studied. The outbred white male Wistar rats, in which metabolic syndrome was induced by consuming a 10% fructose solution instead of drinking water for 42 days, were used. After the induction of metabolic syndrome, the mycelium of G. lucidum in the form of water suspension (a dose of 1 g/kg of the animal's body weight) was administered to animals per os for 7 and 14 days. Glucose concentration was determined using the glucose oxidase method. The content of glycosylated hemoglobin in erythrocytes was determined by the colorimetric method. The concentration of triglycerides, cholesterol, high-density lipoproteins, and low-density lipoproteins in blood plasma was determined by enzymatic methods. A significant decrease in the content of glycosylated hemoglobin was established in animals with metabolic syndrome against the background of administration of the studied suspension. Under the conditions of experimental metabolic syndrome, the administration of mycelium for 7 and 14 days led to a decrease in the concentration of triglycerides by 17.8 and 44.8%, cholesterol by 10.7 and 21.3%, low-density lipoproteins by 14.8 and 28.4%, and to an increase in high-density lipoproteins concentration by 11.9 and 21.5%, compared with metabolic syndrome. The obtained results demonstrate the corrective effect of the suspension of the G. lucidum powdered mycelium on carbohydrate and lipid metabolism, which was directly proportional to the duration of administration.

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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
期刊最新文献
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