身份问题:头颈部鳞状细胞癌的癌症干细胞和肿瘤可塑性。

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2023-02-06 DOI:10.1017/erm.2023.4
Abdelhakim Salem, Tuula Salo
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引用次数: 2

摘要

头颈部鳞状细胞癌(HNSCC)是一种常见但具有侵袭性的肿瘤,它包含复杂的间质和肿瘤成分生态系统,包括癌症干细胞(CSCs)的动态种群。近年来,由于CSCs在致瘤性、转移、治疗抵抗和复发中的作用,CSCs领域的研究得到了越来越多的关注。本文综合评述了近年来有关CSC塑性研究的最新进展,包括新发现的影响因素及其在HNSCC中的应用前景。考虑到我们对口腔微生物群贡献的不断发展的认识以及对描述其特征的相关模型的迫切需要,我们进一步讨论了肿瘤微环境中csc的动态相互作用。总之,CSCs和肿瘤可塑性代表了一个令人兴奋和不断扩大的战场,对癌症治疗具有重大意义,而这在头颈部肿瘤治疗中才刚刚开始受到重视。
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Identity matters: cancer stem cells and tumour plasticity in head and neck squamous cell carcinoma.

Head and neck squamous cell carcinoma (HNSCC) represents frequent yet aggressive tumours that encompass complex ecosystems of stromal and neoplastic components including a dynamic population of cancer stem cells (CSCs). Recently, research in the field of CSCs has gained increased momentum owing in part to their role in tumourigenicity, metastasis, therapy resistance and relapse. We provide herein a comprehensive assessment of the latest progress in comprehending CSC plasticity, including newly discovered influencing factors and their possible application in HNSCC. We further discuss the dynamic interplay of CSCs within tumour microenvironment considering our evolving appreciation of the contribution of oral microbiota and the pressing need for relevant models depicting their features. In sum, CSCs and tumour plasticity represent an exciting and expanding battleground with great implications for cancer therapy that are only beginning to be appreciated in head and neck oncology.

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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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