大鼠记忆中事件序列的性周期和发情周期。

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Behavioral neuroscience Pub Date : 2022-10-01 Epub Date: 2022-03-07 DOI:10.1037/bne0000508
M Jayachandran, P Langius, F Pazos Rego, R P Vertes, T A Allen
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引用次数: 2

摘要

记忆事件序列的能力是情节记忆的基础。虽然啮齿类动物的研究已经在类似情景的空间记忆任务中检查了性和发情周期,但对于依赖于时间上下文表征的事件序列的记忆中的这些生物变量知之甚少。我们研究了在跨物种验证序列记忆任务的训练和测试阶段,性和发情周期在大鼠中的作用(Jayachandran等人,2019)。大鼠接受了在线性轨道两端进行的两个四气味序列记忆任务的训练。训练分为六个连续阶段,从学习戳鼻孔开始,持续时间≥1.2秒;最终通过将鼻子保持在端口中来证明序列记忆,对于序列内气味≥1秒,对于序列外气味<1s。分析了性别和发情周期(发情前期、发情期、中期和发情期)的表现,后者由每日阴道灌洗的细胞组成决定。我们没有发现渐进序列记忆表现存在性别差异的证据,类似于人类执行类似任务(Reeders等人,2021)。同样,在整个发情周期中,没有发现序列记忆表现的差异。一些注意事项是,雄性在使用3气味序列的训练中更快地获得了序列外试验,但这种明显的优势并没有延续到4气味序列中。此外,雄性的戳戳时间总体较短,这似乎与总体反应抑制的降低一致,因为它们的发生与序列需求无关。总之,这些结果表明性和发情周期不是序列记忆能力的主要因素。(PsycInfo数据库记录(c)2022 APA,保留所有权利)。
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Sex and estrous cycle in memory for sequences of events in rats.

The ability to remember sequences of events is fundamental to episodic memory. While rodent studies have examined sex and estrous cycle in episodic-like spatial memory tasks, little is known about these biological variables in memory for sequences of events that depend on representations of temporal context. We investigated the role of sex and estrous cycle in rats during training and testing stages of a cross-species validated sequence memory task (Jayachandran et al., 2019). Rats were trained on a two four-odor sequence memory task delivered on opposite ends of a linear track. Training occurred in six successive stages starting with learning to poke in a nose-port for ≥ 1.2 s; eventually demonstrating sequence memory by holding their nose in the port ≥ 1 s for in-sequence odors and < 1 s for out-of-sequence odors. Performance was analyzed across sex and estrous cycle (proestrus, estrus, metestrus, and diestrus), the latter being determined by cellular composition of a daily vaginal lavage. We found no evidence of sex differences in asymptotic sequence memory performance, similar to humans performing an analogous task (Reeders et al., 2021). Likewise, no differences in sequence memory performance were found across the estrous cycle. Some caveats are that males acquired out-of-sequence trials faster during training with a 3-odor sequence, but this apparent advantage did not carry over to the 4-odor sequence. Additionally, males had shorter poke times overall which seem consistent with a decreased overall response inhibition because they occurred regardless of sequence demands. Together, these results suggest sex and estrous cycle are not major factors in sequence memory capacities. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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