肿瘤上皮-间质转化和巨噬细胞串联在癌症进展中的作用

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Current Osteoporosis Reports Pub Date : 2023-04-01 Epub Date: 2023-02-27 DOI:10.1007/s11914-023-00780-z

Allison M May, Lena Batoon, Laurie K McCauley, Evan T Keller

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摘要

综述的目的：本综述旨在总结最近发表的有关上皮细胞向间充质转化（EMT）在肿瘤进展中的作用、肿瘤微环境中的巨噬细胞以及肿瘤细胞和巨噬细胞之间存在的串扰的研究结果：EMT是肿瘤进展的一个关键过程。与 EMT 变化相关的是，巨噬细胞经常浸润肿瘤。大量证据表明，巨噬细胞与经历了 EMT 的肿瘤细胞之间存在着各种相互影响的机制，从而形成恶性循环，促进肿瘤的侵袭和转移。与肿瘤相关的巨噬细胞和发生 EMT 的肿瘤细胞相互串扰，导致肿瘤进展。这些相互作用为治疗提供了潜在的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of Tumor Epithelial-Mesenchymal Transition and Macrophage Crosstalk in Cancer Progression.

Purpose of review: The purpose of this review is to summarize the recently published findings regarding the role of epithelial to mesenchymal transition (EMT) in tumor progression, macrophages in the tumor microenvironment, and crosstalk that exists between tumor cells and macrophages.

Recent findings: EMT is a crucial process in tumor progression. In association with EMT changes, macrophage infiltration of tumors occurs frequently. A large body of evidence demonstrates that various mechanisms of crosstalk exist between macrophages and tumor cells that have undergone EMT resulting in a vicious cycle that promotes tumor invasion and metastasis. Tumor-associated macrophages and tumor cells undergoing EMT provide reciprocal crosstalk which leads to tumor progression. These interactions provide potential targets to exploit for therapy.

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.