[肠道免疫细胞通过肠-肝轴调控脂肪肝疾病进展的作用]。

Ping Zhang, Mingxin Zhang, Shilin Cheng, Xin Wang, Hongyan Qin
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引用次数: 0

摘要

脂肪肝是世界范围内最常见的慢性肝病之一,肠-肝轴在脂肪肝疾病中的作用日益突出。肠道功能障碍可影响肝脏疾病的发生或进展,验证了肠道免疫细胞的关键作用。大量文献报道,肠道内巨噬细胞、淋巴细胞、树突状细胞(dc)等免疫细胞及其亚群可能通过破坏肠道屏障、肠道脂质转运蛋白失调、介导免疫细胞向肝脏迁移等不同机制调控脂肪肝疾病的进展。
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[The role of intestinal immune cells in regulation of fatty liver disease progress through gut-liver axis].

Fatty liver disease is one of the most prevalent chronic liver disease worldwide and the gut-liver axis is recognized as increasingly prominent in fatty liver disease. Intestinal dysfunction can affect the occurrence or progression of liver disease, therein, validating the critical role of the intestinal immune cells. Enormous literature reported that macrophages, lymphocyte, dendritic cells (DCs) and other immune cells in the gut as well as their subsets may regulate the fatty liver disease progression via different mechanisms, including disruption of intestinal barrier, dysregulation of intestinal lipid transporters and mediating immune cell migration to liver.

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