探索BACH2在获得抗原特异性抗体中的新功能。

IF 4.8 4区 医学 Q2 IMMUNOLOGY International immunology Pub Date : 2023-05-19 DOI:10.1093/intimm/dxac065
Kyoko Ochiai, Kazuhiko Igarashi
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引用次数: 2

摘要

BACH2 [BTB (broad-complex, tramtrak和bric - brac)和CNC (cap 'n' collar)同源物2]被认为是一种转录抑制因子,在调节免疫细胞分化方面具有广泛的功能。在这里,我们关注BACH2在B细胞中的功能,BACH2首次被证明在免疫系统中发挥重要作用。在B细胞中,BACH2协调基因调控网络,促进抗体的类别转换和亲和成熟,同时抑制浆细胞分化。在这种情况下,BACH2通过调节染色质组织来调节基因表达,并与其他转录因子和染色质调节剂如IRF4(干扰素调节因子4)和PC4(正辅激活因子4)合作。此外,我们最近的观察提出了BACH2具有多种功能的可能性,例如基因激活。由于BACH2的功能障碍导致人类免疫缺陷的发生,揭示BACH2的新功能可能为解决BACH2如何预防这些疾病提供线索。
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Exploring novel functions of BACH2 in the acquisition of antigen-specific antibodies.

BACH2 [BTB (broad-complex, tramtrak and bric à brac) and CNC (cap 'n' collar) homolog 2] is known as a transcriptional repressor and broadly functions in regulating immune cell differentiation. Here, we focus on BACH2 function in B cells, where BACH2 was first shown to play an important role in the immune system. In B cells, BACH2 orchestrates the gene regulatory network that promotes class switch and affinity maturation of antibodies and simultaneously represses plasma-cell differentiation. In this context, BACH2 regulates gene expression by modulating chromatin organization, cooperatively with other transcription factors and chromatin regulators, such as IRF4 (interferon regulatory factor 4) and PC4 (positive coactivator 4), respectively. In addition, our recent observation raises the possibility that BACH2 has diverse functions, such as those in gene activation. Since dysfunction of BACH2 leads to the onset of human immune deficiencies, revealing new functions of BACH2 may give a cue to solve how BACH2 contributes to preventing these diseases.

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来源期刊
International immunology
International immunology 医学-免疫学
CiteScore
9.30
自引率
2.30%
发文量
51
审稿时长
6-12 weeks
期刊介绍: International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.
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