{"title":"多西他赛致鞭毛性红斑1例报告及简要回顾。","authors":"Jerbi Asma, Kastalli Sarrah, Charfi Ons, Dhaghfous Riadh, El Aidli Sihem","doi":"10.2174/1574886317666220613155550","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Flagellate erythema is a distinctive morphologic reaction pattern recognized by whiplash-like pruritic erythematous eruption. It is usually encountered in patients receiving bleomycin. Only one case of docetaxel-induced flagellate erythema is reported in the literature.</p><p><strong>Case report: </strong>Herein, we report a rare case of docetaxel-induced flagellate erythema in a 53 years old woman with no particular medical history treated with docetaxel for metastatic adenocarcinoma of her right breast. Seven days after the third course, she developed multiple lineal and parallel pruritic erythematous streaks mainly on her chest and abdomen. The cutaneous erythema disappeared gradually over 10 days, leaving hyper-pigmented post-inflammatory linear scars lasting two weeks. The same reaction reappeared after the fourth and the fifth docetaxel course.</p><p><strong>Conclusion: </strong>Flagellate erythema has been reported as an adverse drug reaction secondary to several antineoplastic molecules, including docetaxel. Further studies are needed to discover its underlying mechanisms in order to figure out better treatment plans and prevention.</p>","PeriodicalId":10777,"journal":{"name":"Current drug safety","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Docetaxel-induced Flagellate Erythema - Case Report and Brief Review.\",\"authors\":\"Jerbi Asma, Kastalli Sarrah, Charfi Ons, Dhaghfous Riadh, El Aidli Sihem\",\"doi\":\"10.2174/1574886317666220613155550\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Flagellate erythema is a distinctive morphologic reaction pattern recognized by whiplash-like pruritic erythematous eruption. It is usually encountered in patients receiving bleomycin. Only one case of docetaxel-induced flagellate erythema is reported in the literature.</p><p><strong>Case report: </strong>Herein, we report a rare case of docetaxel-induced flagellate erythema in a 53 years old woman with no particular medical history treated with docetaxel for metastatic adenocarcinoma of her right breast. Seven days after the third course, she developed multiple lineal and parallel pruritic erythematous streaks mainly on her chest and abdomen. The cutaneous erythema disappeared gradually over 10 days, leaving hyper-pigmented post-inflammatory linear scars lasting two weeks. The same reaction reappeared after the fourth and the fifth docetaxel course.</p><p><strong>Conclusion: </strong>Flagellate erythema has been reported as an adverse drug reaction secondary to several antineoplastic molecules, including docetaxel. Further studies are needed to discover its underlying mechanisms in order to figure out better treatment plans and prevention.</p>\",\"PeriodicalId\":10777,\"journal\":{\"name\":\"Current drug safety\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current drug safety\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1574886317666220613155550\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current drug safety","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1574886317666220613155550","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Docetaxel-induced Flagellate Erythema - Case Report and Brief Review.
Introduction: Flagellate erythema is a distinctive morphologic reaction pattern recognized by whiplash-like pruritic erythematous eruption. It is usually encountered in patients receiving bleomycin. Only one case of docetaxel-induced flagellate erythema is reported in the literature.
Case report: Herein, we report a rare case of docetaxel-induced flagellate erythema in a 53 years old woman with no particular medical history treated with docetaxel for metastatic adenocarcinoma of her right breast. Seven days after the third course, she developed multiple lineal and parallel pruritic erythematous streaks mainly on her chest and abdomen. The cutaneous erythema disappeared gradually over 10 days, leaving hyper-pigmented post-inflammatory linear scars lasting two weeks. The same reaction reappeared after the fourth and the fifth docetaxel course.
Conclusion: Flagellate erythema has been reported as an adverse drug reaction secondary to several antineoplastic molecules, including docetaxel. Further studies are needed to discover its underlying mechanisms in order to figure out better treatment plans and prevention.
期刊介绍：
Current Drug Safety publishes frontier articles on all the latest advances on drug safety. The journal aims to publish the highest quality research articles, reviews and case reports in the field. Topics covered include: adverse effects of individual drugs and drug classes, management of adverse effects, pharmacovigilance and pharmacoepidemiology of new and existing drugs, post-marketing surveillance. The journal is essential reading for all researchers and clinicians involved in drug safety.
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