冰山一角——长链非编码rna在急性髓性白血病中的作用。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-11-01 Epub Date: 2023-06-02 DOI:10.1002/wrna.1796
Patrick Connerty, Richard B Lock
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引用次数: 0

摘要

长链非编码RNA (lncrna)传统上被定义为长度超过200个核苷酸的RNA转录物,没有蛋白质编码潜力。lncrna已被发现在各种类型的癌症中失调,包括致命的造血癌症——急性髓性白血病(AML)。目前,AML的生存率已经达到平台期,需要新的治疗靶点和生物标志物来改善治疗选择和疾病的生存率。因此,鉴定lncrna作为AML的新型生物标志物和治疗靶点具有重大的益处。在这篇综述中,我们评估了最近发现lncRNAs在AML中是重要分子的关键研究,并总结了目前对AML中lncRNAs的认识。我们深入研究了lncRNA在AML中具体作用的例子,如驱动增殖、分化阻断和治疗耐药性,以及它们作为肿瘤抑制因子的功能和作为生物标志物的效用。本文分类如下:RNA在疾病和发展> RNA在疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The tip of the iceberg-The roles of long noncoding RNAs in acute myeloid leukemia.

Long noncoding RNAs (lncRNAs) are traditionally defined as RNA transcripts longer than 200 nucleotides that have no protein coding potential. LncRNAs have been identified to be dysregulated in various types of cancer, including the deadly hematopoietic cancer-acute myeloid leukemia (AML). Currently, survival rates for AML have reached a plateau necessitating new therapeutic targets and biomarkers to improve treatment options and survival from the disease. Therefore, the identification of lncRNAs as novel biomarkers and therapeutic targets for AML has major benefits. In this review, we assess the key studies which have recently identified lncRNAs as important molecules in AML and summarize the current knowledge of lncRNAs in AML. We delve into examples of the specific roles of lncRNA action in AML such as driving proliferation, differentiation block and therapy resistance as well as their function as tumor suppressors and utility as biomarkers. This article is categorized under: RNA in Disease and Development > RNA in Disease.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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