[中国HIV/AIDS患者血脂综合管理专家共识]。

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引用次数: 1

摘要

人类免疫缺陷病毒(HIV)感染和获得性免疫缺陷综合征(AIDS)是关系到人类健康的全球性公共卫生问题之一。血脂异常是心血管事件的主要危险因素之一,而血浆胆固醇水平升高与50%以上冠心病的发病有关。艾滋病毒/艾滋病患者患心血管疾病的风险高于正常人群。除了传统的危险因素外,病毒复制和次优治疗增加了艾滋病毒/艾滋病患者发生动脉粥样硬化性冠状动脉血管疾病(ASCVD)的风险。因此,深入了解脂质代谢和失调特征,有效控制常规ASCVD危险因素,加强脂质管理措施,对改善HIV/AIDS患者的长期预后和生活质量具有重要意义。然而,到目前为止,在长期抗逆转录病毒治疗(ART)下HIV/ aids人群的脂质管理方面还没有特别的共识。基于ART在中国的现状以及基础研究和临床试验的前沿成果,我们邀请国内感染性疾病和心血管疾病领域的专家,共同撰写本关于中国HIV/AIDS患者脂质综合管理的专家共识。
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[Chinese expert consensus on integrated lipid management in HIV/AIDS].

Human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) are one of the global public health issues concerning health of human beings. Dyslipidemia is one of the major risk factors for cardiovascular events, while elevation of plasma cholesterol levels is associated with the onset of over 50% coronary heart disease. The incidence risks of cardiovascular diseases are higher in HIV/AIDS patients than those in normal populations. In addition to conventional risk factors, viral duplication and suboptimal treatments increase risks of atherosclerotic coronary vascular disease (ASCVD) in HIV/AIDS patients. Thus, a deep knowledge of lipid metabolism and dysregulation profiles, an efficient control of conventional ASCVD risk factors, as well as strengthened measures to lipid management, are of significance to improve long-term prognosis and life quality for HIV/AIDS patients. However, up to date, there is no particular consensus on lipid management for HIV/ADIS populations under long-term antiretroviral therapies (ART). Hereby, based on current status quo of ART in China and frontier achievements of fundamental researches and clinical trials, we invited domestic experts in fields of infectious diseases and cardiovascular diseases to compose this expert consensus on the integrated management of lipid in HIV/AIDS patients in China.

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