对眼部病原真菌的免疫力。

IF 7.4 2区 医学 Q1 IMMUNOLOGY Seminars in Immunology Pub Date : 2023-05-01 DOI:10.1016/j.smim.2023.101753
Serena Abbondante , Sixto M. Leal , Heather L. Clark , Bridget Ratitong , Yan Sun , Li-Jun Ma , Eric Pearlman
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引用次数: 1

摘要

镰刀菌、曲霉菌和念珠菌是在美国和世界范围内引起视力障碍和失明的重要真菌病原体。这篇综述将总结角膜感染的流行病学和临床特征,并讨论在临床疾病中发挥重要作用的免疫和炎症反应。此外,我们还描述了在感染的角膜中存活所需的真菌毒力因子,以及中性粒细胞在真菌杀死、组织损伤和细胞因子产生中的活性。
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Immunity to pathogenic fungi in the eye

Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role in clinical disease. In addition, we describe fungal virulence factors that are required for survival in infected corneas, and the activities of neutrophils in fungal killing, tissue damage and cytokine production.

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来源期刊
Seminars in Immunology
Seminars in Immunology 医学-免疫学
CiteScore
11.40
自引率
1.30%
发文量
50
审稿时长
89 days
期刊介绍: Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.
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