老虎(Panthera tigris)肾癌转移扩散:形态学和免疫组织化学研究。

Pub Date : 2022-12-31 DOI:10.12834/VetIt.2475.16553.2

Lorella Maniscalco, Pier Luigi Acutis, Cristina Biolatti, Daniele R Laguardia, Alessia Di Blasio, Alessandro Dondo, Elena Bozzetta, Katia Varello

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摘要

一只12岁的完整雄性底格里斯豹因疼痛和体重减轻而被安乐死。坏死镜检查显示肿瘤肿块扩张至左肾盂，并转移至局部淋巴结、肾上腺和肺。免疫组织化学表征显示细胞角蛋白和波形蛋白共表达，PAX8和c‑KIT均阴性。结合组织化学和免疫组织化学结果，我们将肿瘤分类为肾细胞癌并转移扩散。本报告提供了对黑豹肾细胞癌的形态学和免疫组织化学特征的见解。

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Renal carcinoma with metastatic spread in a tiger (Panthera tigris): morphological and immunohistochemical study.

A 12‑year‑old intact male Panthera tigris presented with pain and weight loss was euthanatized. Necroscopical examination revealed a neoplastic mass expanding to the left renal pelvis with metastatic dissemination to local lymph node, adrenal gland, and lung. Immunohistochemical characterization was performed revealing co‑expression of both cytokeratin and vimentin and negativity for both PAX8 and c‑KIT. Considering histochemical and immunohistochemical results the tumour was classified as renal cell carcinoma with metastatic spread. This report provides insights into the morphological and immunohistochemical features of renal cell carcinoma in Panthera tigris.

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