Judith A Aberg, Anthony Mills, Santiago Moreno, Jill Slater, Manyu Prakash, Andrew Clark
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引用次数: 1
摘要
接受过大量治疗的艾滋病毒感染者的抗逆转录病毒治疗选择有限，并面临许多挑战，使其疾病管理复杂化。目前仍需要为这一人群提供新的抗逆转录病毒药物和治疗策略。我们回顾了纳入HIV感染者的研究设计、基线特征和临床试验结果。PubMed文献检索检索了1995- 2020年间发表的文章，按试验开始日期分组(1995-2009,N = 89;2010-2014, n = 3;2015-2020年，N = 2)。2010年后，HTE参与者的临床试验数量明显下降。参与者的特征和研究设计显示出随时间变化的趋势。随着艾滋病毒感染者的治疗策略取得进展，我们必须超越病毒学抑制，考虑这一复杂异质性人群的更广泛需求。
The evolution of clinical study design in heavily treatment-experienced persons with HIV: A critical review.
Heavily treatment-experienced (HTE) persons with HIV have limited options for antiretroviral therapy and face many challenges, complicating their disease management. There is an ongoing need for new antiretrovirals and treatment strategies for this population. We reviewed the study designs, baseline characteristics, and results of clinical trials that enrolled HTE persons with HIV. A PubMed literature search retrieved articles published between 1995 and 2020, which were grouped by trial start date (1995-2009, N = 89; 2010-2014, N = 3; 2015-2020, N = 2). Clinical trials in HTE participants markedly declined post-2010. Participant characteristics and study designs showed changes in trends over time. As treatment strategies for HTE persons with HIV progress, we must look beyond virologic suppression to consider the broader needs of this complex heterogeneous population.
期刊介绍：
Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases.
The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.
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