脑灌注如何与儿童癌症幸存者的功能预后相关?

IF 1.6 4区心理学 Q3 PSYCHOLOGY Developmental Neuropsychology Pub Date : 2023-07-01 DOI:10.1080/87565641.2023.2215360

Kirstin Schuerch, Matthias Grieder, Valentin Benzing, Valerie Siegwart, Andrea Federspiel, Nedelina Slavova, Claus Kiefer, Jochen Roessler, Regula Everts

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引用次数: 0

摘要

儿童癌症幸存者(PCS)经历功能困难和大脑改变。然而，对于PCS的脑灌注及其与功能结局(认知和运动表现)的关系知之甚少。我们检查了非脑肿瘤PCS的脑血流量(CBF)以及CBF与年龄和功能结局之间的关系。包括40名PCS和40名年龄相当的对照组。脑血流在实验组和对照组之间没有差异。CBF仅在对照组中随年龄下降。在PCS中，CBF与功能预后相关。我们的数据表明，年龄与幸存者脑血流之间的关系发生了改变，癌症后脑行为机制更强。

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How is Cerebral Perfusion Associated with Functional Outcome in Pediatric Cancer Survivors?

Pediatric cancer survivors (PCS) experience functional difficulties and brain alterations. However, little is known about cerebral perfusion and its relationship to functional outcome (cognitive and motor performance) in PCS. We examined cerebral blood flow (CBF) in non-brain tumor PCS and the associations between CBF and age, as well as functional outcome. Forty PCS and 40 age-comparable controls were included. CBF did not differ between PCS and controls. CBF decreased with age only in controls. In PCS, CBF was associated with functional outcome. Our data indicate an altered relationship between age and CBF in survivors, with stronger brain-behavior mechanisms after cancer.

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来源期刊

Developmental Neuropsychology 医学-心理学

CiteScore

2.80

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Devoted to exploring relationships between brain and behavior across the life span, Developmental Neuropsychology publishes scholarly papers on the appearance and development of behavioral functions, such as language, perception, and social, motivational and cognitive processes as they relate to brain functions and structures. Appropriate subjects include studies of changes in cognitive function—brain structure relationships across a time period, early cognitive behaviors in normal and brain-damaged children, plasticity and recovery of function after early brain damage, the development of complex cognitive and motor skills, and specific and nonspecific disturbances, such as learning disabilities, mental retardation, schizophrenia, stuttering, and developmental aphasia. In the gerontologic areas, relevant subjects include neuropsychological analyses of normal age-related changes in brain and behavioral functions, such as sensory, motor, cognitive, and adaptive abilities; studies of age-related diseases of the nervous system; and recovery of function in later life. Empirical studies, research reviews, case reports, critical commentaries, and book reviews are featured in each issue. By publishing both basic and clinical studies of the developing and aging brain, the journal encourages additional scholarly work that advances understanding of the field of lifespan developmental neuropsychology.