一种罕见的新生儿疾病:短暂性新生儿重症肌无力的预期治疗。

IF 0.8 4区医学 Q4 PEDIATRICS Turkish Journal of Pediatrics Pub Date : 2023-01-01 DOI:10.24953/turkjped.2022.717

Farin Masra, Shareena Ishak, Fook-Choe Cheah

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引用次数: 0

摘要

背景:短暂性新生儿重症肌无力(TNMG)是一种获得性疾病，发生在重症肌无力母亲所生婴儿的10 - 20%。尽管它是一种自限性疾病，但如果不及时诊断，并且在需要时不采取权宜之计的支持性呼吸管理，它可能会危及生命。病例:这里我们描述了三名患有TNMG的婴儿。其中两人在生命24小时内出现TNMG症状，但一人在生命43小时出现症状。其中1例患者表现为非典型TNMG，伴有挛缩和肌张力过低。另外两名婴儿幸存下来的典型形式TNMG与低张力和吮吸不良。所有病例经保守治疗后一至两周内自行消退。结论:重症肌无力母亲所生的婴儿需要在出生后48至72小时内密切监测TNMG症状。然而，大多数婴儿的TNMG经过一个良性过程，并在期待的护理下自发消退。

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The expectant management of a rare neonatal disease: transient neonatal myasthenia gravis.

Background: Transient neonatal myasthenia gravis (TNMG) is an acquired disease which occurs in 10 to 20% of infants born to a mother with myasthenia gravis. Even though it is a self-limiting disorder, it may potentially be life-threatening if prompt diagnosis is not made, and expedient supportive respiratory management is not initiated when required.

Case: Here we describe three infants with TNMG. Two of them developed symptoms of TNMG within 24 hours of life, but one developed symptoms at 43 hours of life. One of the patients had an atypical form of TNMG with contracture and hypotonia. The other two infants survived a typical form of TNMG with hypotonia and poor sucking. All cases resolved spontaneously by one to two weeks of life with conservative management.

Conclusions: Infants born to mothers with myasthenia gravis need to be monitored closely for symptoms of TNMG for the first 48 to 72 hours of life. However, the majority of infants with TNMG traverse a benign course and resolve spontaneously with expectant care.

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来源期刊

Turkish Journal of Pediatrics 医学-小儿科

CiteScore

1.40

自引率

0.00%

发文量

122

审稿时长

6-12 weeks

期刊介绍： The Turkish Journal of Pediatrics is a multidisciplinary, peer reviewed, open access journal that seeks to publish research to advance the field of Pediatrics. The Journal publishes original articles, case reports, review of the literature, short communications, clinicopathological exercises and letter to the editor in the field of pediatrics. Articles published in this journal are evaluated in an independent and unbiased, double blinded peer-reviewed fashion by an advisory committee.