基因多态性影响胃肠道间质瘤患者术后伊马替尼血浆水平和水肿。

IF 1.9 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics Pub Date : 2023-05-01 DOI:10.2217/pgs-2022-0171
Xuehui Jiang, Qun Fu, Ying Kong, Hong Liu, Kaisaner Rexiti, Hongwei Peng, Pin Xiao, Xiaohua Wei
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引用次数: 1

摘要

目的:探讨遗传多态性在胃肠道间质瘤患者术后伊马替尼浓度和水肿中的作用。方法:探讨遗传多态性、伊马替尼浓度与水肿的关系。结果:rs683369 g等位基因和rs2231142 t等位基因携带者的伊马替尼浓度显著增高。≥2级眶周水肿与rs2072454携带2个c等位基因相关,校正比值比为2.85,与rs1867351携带2个t等位基因相关,校正比值比为3.42,与rs11636419携带2个a等位基因相关,校正比值比为3.15。结论:rs683369和rs2231142影响伊马替尼的代谢;Rs2072454、rs1867351和rs11636419与≥2级眶周水肿相关。
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Gene polymorphisms affect postoperative imatinib plasma levels and edema in adults with gastrointestinal stromal tumor.

Aim: To assess the role of genetic polymorphisms in postoperative imatinib concentrations and edema in patients with gastrointestinal stromal tumor. Methods: The relationships between genetic polymorphisms, imatinib concentrations and edema were explored. Results: Carriers of the rs683369 G-allele and rs2231142 T-allele had significantly higher imatinib concentrations. Grade ≥2 periorbital edemas were related to the carriership of two C-alleles in rs2072454 with an adjusted odds ratio of 2.85, two T-alleles in rs1867351 with an adjusted odds ratio of 3.42 and two A-alleles in rs11636419 with an adjusted odds ratio of 3.15. Conclusion: rs683369 and rs2231142 affect the metabolism of imatinib; rs2072454, rs1867351 and rs11636419 are related to grade ≥2 periorbital edemas.

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来源期刊
Pharmacogenomics
Pharmacogenomics 医学-药学
CiteScore
3.40
自引率
9.50%
发文量
88
审稿时长
4-8 weeks
期刊介绍: Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.
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