Metsihet Mohammed Nuru, Temesgen Bizuayehu Wube, Demissie Assegu Fenta
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Hematological parameters from the blood sample were analyzed using Ruby Cell-Dyne 300 hematology auto-analyzer. The data were analyzed using SPSS version 20. Logistic regression was used to assess the predictors of cytopenia among the study participants. P-values of less than 0.05 are considered statistically significant.</p><p><strong>Results: </strong>Two hundred seventy-three HAART-experienced children were enrolled in this study, and 50.9% were females. At baseline, 40.7% of children were anemic. The overall magnitude of cytopenia among the study participants was 26.7%. The prevalence of anemia, thrombocytopenia, leucopenia and neutropenia among children was 11.4%, 4.0%, 14.3%, and 18.3%, respectively. Patients with an undetectable viral load (AOR = 0.5, CI = 0.3-0.9) are 50% less likely to report cytopenia. HAART-experienced children living in rural areas are more likely to develop cytopenia (AOR = 2.6, CI = 1.3-5.2) than those living in urban areas.</p><p><strong>Conclusion: </strong>Hematologic abnormalities are common problems among children on highly active antiretroviral therapy. 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引用次数: 0
摘要
背景:hiv感染儿童中最常见的异常是血细胞减少，这是一种血液学并发症，其特征是任何一种血细胞的减少。它与较高的发病率和死亡率有关。因此，本研究旨在评估在接受高效抗逆转录病毒治疗(HAART)的hiv阳性儿童中细胞减少的患病率及其相关因素。方法:对2020年7月至9月在医院接受HAART治疗的hiv阳性儿童进行横断面研究设计。使用结构化问卷收集研究参与者的社会人口学和临床特征数据。使用Ruby Cell-Dyne 300血液学自动分析仪分析血样的血液学参数。数据采用SPSS version 20进行分析。Logistic回归用于评估研究参与者中细胞减少的预测因素。p值小于0.05被认为具有统计学意义。结果:273名经历过haart治疗的儿童被纳入本研究，其中50.9%为女性。在基线时，40.7%的儿童贫血。研究参与者中细胞减少的总体程度为26.7%。儿童贫血、血小板减少、白细胞减少和中性粒细胞减少的患病率分别为11.4%、4.0%、14.3%和18.3%。无法检测到病毒载量的患者(AOR = 0.5, CI = 0.3-0.9)报告细胞减少的可能性要低50%。生活在农村地区经历过haart治疗的儿童比生活在城市地区的儿童更容易发生细胞减少症(AOR = 2.6, CI = 1.3-5.2)。结论:在接受高效抗逆转录病毒治疗的儿童中，血液学异常是常见问题。因此，建议在适当的治疗干预后进行血液学和免疫学的常规检查。
Magnitude and Factors Associated with Cytopenia Among Children on Highly Active Antiretroviral Therapy at Hawassa University College of Medicine and Health Science, Sidama Region, Southern Ethiopia.
Background: The most common abnormality in HIV-infected children is cytopenia, a hematological complication characterized by a decline in any of the blood cell lines. It is associated with a higher risk of morbidity and mortality. Therefore, this study aimed to assess the prevalence and associated factors of cytopenia among HIV-positive children on highly active antiretroviral therapy (HAART).
Methods: Hospital-based cross-sectional study design was conducted on HIV-positive children on HAART from July to September 2020. Socio-demographic and clinical characteristics of the study participants' data were collected using a structured questionnaire. Hematological parameters from the blood sample were analyzed using Ruby Cell-Dyne 300 hematology auto-analyzer. The data were analyzed using SPSS version 20. Logistic regression was used to assess the predictors of cytopenia among the study participants. P-values of less than 0.05 are considered statistically significant.
Results: Two hundred seventy-three HAART-experienced children were enrolled in this study, and 50.9% were females. At baseline, 40.7% of children were anemic. The overall magnitude of cytopenia among the study participants was 26.7%. The prevalence of anemia, thrombocytopenia, leucopenia and neutropenia among children was 11.4%, 4.0%, 14.3%, and 18.3%, respectively. Patients with an undetectable viral load (AOR = 0.5, CI = 0.3-0.9) are 50% less likely to report cytopenia. HAART-experienced children living in rural areas are more likely to develop cytopenia (AOR = 2.6, CI = 1.3-5.2) than those living in urban areas.
Conclusion: Hematologic abnormalities are common problems among children on highly active antiretroviral therapy. Therefore, routine investigation of hematological and immunological changes following appropriate therapeutic interventions is recommended.
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