Appetizer on soft matter physics concepts in mechanobiology

Mechanosensing, the active responses of cells to the mechanics on multiple scales, plays an indispensable role in regulating cell behaviors and determining the fate of biological entities such as tissues and organs. Here, I aim to give a pedagogical illustration of the fundamental concepts of soft matter physics that aid in understanding biomechanical phenomena from the scale of tissues to proteins. Examples of up-to-date research are introduced to elaborate these concepts. Challenges in applying physics models to biology have also been discussed for biologists and physicists to meet in the field of mechanobiology.