{"title":"大龄儿童颅内感染流感嗜血杆菌血清型 a 的报告。","authors":"Varvara Probst, Fadi Shahoud, Aaron Fletcher Osborne, Ana Alvarez, Nizar Maraqa, Ayesha Mirza","doi":"10.1002/ped4.12369","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong><i>Haemophilus influenzae</i> (Hi) is subdivided into typeable (a-f) and non-typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age.</p><p><strong>Case presentation: </strong>We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area.</p><p><strong>Conclusion: </strong>Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/ef/PED4-7-132.PMC10262899.pdf","citationCount":"0","resultStr":"{\"title\":\"Report of <i>Haemophilus Influenzae</i> serotype a intracranial infections in older children.\",\"authors\":\"Varvara Probst, Fadi Shahoud, Aaron Fletcher Osborne, Ana Alvarez, Nizar Maraqa, Ayesha Mirza\",\"doi\":\"10.1002/ped4.12369\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong><i>Haemophilus influenzae</i> (Hi) is subdivided into typeable (a-f) and non-typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age.</p><p><strong>Case presentation: </strong>We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area.</p><p><strong>Conclusion: </strong>Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.</p>\",\"PeriodicalId\":19992,\"journal\":{\"name\":\"Pediatric Investigation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2023-03-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/ef/PED4-7-132.PMC10262899.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Investigation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ped4.12369\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/6/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ped4.12369","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/6/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
摘要
导言：流感嗜血杆菌（Hi）又分为可分型（a-f）和不可分型两类。血清型 b 型流感嗜血杆菌（Hib）一直是造成入侵性感染的重要病原体之一。然而，在广泛接种 Hib 疫苗后，过去几十年中出现了其他 Hi 血清型，特别是 Hi 血清型 a（Hia），主要发生在 5 岁以下儿童中：病例介绍：我们介绍了两例颅内严重感染病例，患者年龄均大于 5 岁，且在短时间内和同一地理区域内检测到 Hia：为了更好地了解 Hia 的临床和流行病学特征，有必要对全球所有年龄组的 Hia 相关疾病进行流行病学研究和监测。结论：需要对全球所有年龄组的 Hia 相关疾病进行流行病学研究和监测，以更好地了解 Hia 的临床和流行病学特征，从而为开发可保护所有年龄组儿童的 Hia 候选疫苗建立一个平台。
Report of Haemophilus Influenzae serotype a intracranial infections in older children.
Introduction: Haemophilus influenzae (Hi) is subdivided into typeable (a-f) and non-typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age.
Case presentation: We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area.
Conclusion: Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.
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