三羧酸(TCA)循环:一个可延展的代谢网络,以对抗细胞压力。

IF 6.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2023-02-01 DOI:10.1080/10409238.2023.2201945
Alex MacLean, Felix Legendre, Vasu D Appanna
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引用次数: 2

摘要

三羧酸(TCA)循环是一种从细菌到人类的原始代谢途径。尽管这个网络通常被认为主要是通过氧化磷酸化促进ATP合成的能量产生引擎,但越来越多的证据表明,这个代谢中心协调了各种关键的生物过程。它通过调节NADH/NADPH稳态,清除活性氧,通过底物水平磷酸化产生ATP,信号传导和提供代谢物来平息一系列细胞破坏,在对抗细胞应激中发挥重要作用。这篇综述详细阐述了在大多数微生物系统中,由金属毒性、氧化张力、营养挑战和抗生素损伤等非生物胁迫引起的该网络重编程如何对对抗这些条件至关重要。提出了应激源和TCA循环参与者之间的串扰,导致代谢物和核苷酸浓度的变化,旨在对抗非生物挑战。本文讨论了由与该代谢中心相关的不同酶介导的代谢物的微调。酶活性的调节旨在产生代谢的部分,致力于响应细胞的扰动被解释。我们必须认识到,这个古老的代谢网络在其公认的传统角色之外,还具有多种生理功能。
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The tricarboxylic acid (TCA) cycle: a malleable metabolic network to counter cellular stress.

The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from bacteria to humans. Although this network is often viewed primarily as an energy producing engine fueling ATP synthesis via oxidative phosphorylation, mounting evidence reveals that this metabolic hub orchestrates a wide variety of pivotal biological processes. It plays an important part in combatting cellular stress by modulating NADH/NADPH homeostasis, scavenging ROS (reactive oxygen species), producing ATP by substrate-level phosphorylation, signaling and supplying metabolites to quell a range of cellular disruptions. This review elaborates on how the reprogramming of this network prompted by such abiotic stress as metal toxicity, oxidative tension, nutrient challenge and antibiotic insult is critical for countering these conditions in mostly microbial systems. The cross-talk between the stressors and the participants of TCA cycle that results in changes in metabolite and nucleotide concentrations aimed at combatting the abiotic challenge is presented. The fine-tuning of metabolites mediated by disparate enzymes associated with this metabolic hub is discussed. The modulation of enzymatic activities aimed at generating metabolic moieties dedicated to respond to the cellular perturbation is explained. This ancient metabolic network has to be recognized for its ability to execute a plethora of physiological functions beyond its well-established traditional roles.

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来源期刊
CiteScore
14.90
自引率
0.00%
发文量
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期刊介绍: As the discipline of biochemistry and molecular biology have greatly advanced in the last quarter century, significant contributions have been made towards the advancement of general medicine, genetics, immunology, developmental biology, and biophysics. Investigators in a wide range of disciplines increasingly require an appreciation of the significance of current biochemical and molecular biology advances while, members of the biochemical and molecular biology community itself seek concise information on advances in areas remote from their own specialties. Critical Reviews in Biochemistry and Molecular Biology believes that well-written review articles prove an effective device for the integration and meaningful comprehension of vast, often contradictory, literature. Review articles also provide an opportunity for creative scholarship by synthesizing known facts, fruitful hypotheses, and new concepts. Accordingly, Critical Reviews in Biochemistry and Molecular Biology publishes high-quality reviews that organize, evaluate, and present the current status of high-impact, current issues in the area of biochemistry and molecular biology. Topics are selected on the advice of an advisory board of outstanding scientists, who also suggest authors of special competence. The topics chosen are sufficiently broad to interest a wide audience of readers, yet focused enough to be within the competence of a single author. Authors are chosen based on their activity in the field and their proven ability to produce a well-written publication.
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