患者报告的结果是肌内干扰素β-1a使用者疾病失能的最强预测因子。

IF 2.3 Q3 CLINICAL NEUROLOGY Neurodegenerative disease management Pub Date : 2023-06-01 DOI:10.2217/nmt-2022-0008
Caila B Vaughn, Katelyn S Kavak, Dejan Jakimovski, Natasha Qutab, Robin Avila, Megan Vignos, Bianca Weinstock-Guttman
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引用次数: 3

摘要

患者报告结果(PROs)是多发性硬化症(pwMS)患者常规临床护理的重要指标。材料:从纽约州多发性硬化症协会中回顾性纳入干扰素-β-1a (IFN-β-1a)治疗的646例pwMS。收集入组时和3年随访时的临床和PRO数据。根据年龄、扩展残疾状态量表(EDSS)评分和疾病持续时间对病情稳定和残疾恶化的PwMS进行1:1匹配。根据试验标准确定残疾恶化。结果:未来EDSS恶化的PwMS有更高的基线和随访时间-25英尺步行(6.6 vs 5.5 s;9.1 vs 5.5 s;结论:重度疲劳和下肢功能受限是pwMS患者未来残疾恶化的重要预测因素。
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Patient-reported outcomes are the strongest predictors of disease disability in intramuscular interferon β-1a users.

Introduction: Patient-reported outcomes (PROs) are valuable measures for routine clinical care of people with multiple sclerosis (pwMS). Materials: 646 pwMS treated with interferon-β-1a (IFN-β-1a) were retrospectively included from the New York State Multiple Sclerosis Consortium. Clinical and PRO data at enrollment and 3 year follow-up were collected. PwMS with stable disease and disability worsening were matched (1:1) based on age, Expanded Disability Status Scale (EDSS) scores and disease duration. Disability worsening was determined based on trial criteria. Results: PwMS with future EDSS worsening had higher baseline and follow-up timed-25-foot walk (6.6 vs 5.5 s; 9.1 vs 5.5 s; p < 0.001) when compared with stable pwMS. Worsening pwMS reported higher baseline difficulties in getting up (odds ratio [OR] = 2.4; p = 0.009), climbing stairs (OR = 1.6; p = 0.024) and standing (OR = 2.2; p < 0.001). Worsening pwMS reported greater lower limb limitations (OR = 2.3; p = 0.004) and fatigue (OR = 1.8; p = 0.002). Conclusion: Higher fatigue and lower limb functional limitations are significant predictors of future disability worsening in pwMS.

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