2型糖尿病患者负荷后胰岛素分泌模式与血糖状态和糖尿病并发症相关

IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-04-01 DOI:10.1055/a-2018-4299
Jiajia Jiang, Yuhao Li, Feng Li, Yan He, Lijuan Song, Kun Wang, Wenjun You, Zhang Xia, Yingting Zuo, Xin Su, Qi Zhai, Yibo Zhang, Herbert Gaisano, Deqiang Zheng
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引用次数: 0

摘要

背景:研究负荷后胰岛素分泌的不同模式是否可以识别2型糖尿病(T2DM)的异质性。方法:选取2019年1月至2021年10月济宁市第一人民医院住院T2DM患者625例。对T2DM患者进行140 g馒头试验(SBMT),记录0、60、120、180 min时的血糖、胰岛素、c肽水平。为了避免外源性胰岛素的影响,根据负荷后c肽的分泌模式,通过潜在类别轨迹分析将患者分为三个不同的类别。分别采用多元线性回归和多元逻辑回归比较三组患者短期和长期血糖状态及并发症发生率的差异。结果:两组长期血糖状态(如:(如糖化血红蛋白)和短期血糖状态(如糖化血红蛋白)。(平均血糖,时间范围)。在白天、白天和夜间,短期血糖状态的差异相似。重度糖尿病视网膜病变和动脉粥样硬化的患病率在3类人群中呈下降趋势。结论:负荷后胰岛素分泌模式可以很好地识别T2DM患者短期和长期血糖状态的异质性及并发症的发生率,为及时调整T2DM患者的治疗方案,促进个性化治疗提供建议。
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Post-Load Insulin Secretion Patterns are Associated with Glycemic Status and Diabetic Complications in Patients with Type 2 Diabetes Mellitus.

Background: To examine whether the different patterns of post-load insulin secretion can identify the heterogeneity of type 2 diabetes mellitus (T2DM).

Methods: Six hundred twenty-five inpatients with T2DM at Jining No. 1 People's Hospital were recruited from January 2019 to October 2021. The 140 g steamed bread meal test (SBMT) was conducted on patients with T2DM, and glucose, insulin, and C-peptide levels were recorded at 0, 60, 120, and 180 min. To avoid the effect of exogenous insulin, patients were categorized into three different classes by latent class trajectory analysis based on the post-load secretion patterns of C-peptide. The difference in short- and long-term glycemic status and prevalence of complications distributed among the three classes were compared by multiple linear regression and multiple logistic regression, respectively.

Results: There were significant differences in long-term glycemic status (e. g., HbA1c) and short-term glycemic status (e. g., mean blood glucose, time in range) among the three classes. The difference in short-term glycemic status was similar in terms of the whole day, daytime, and nighttime. The prevalence of severe diabetic retinopathy and atherosclerosis showed a decreasing trend among the three classes.

Conclusions: The post-load insulin secretion patterns could well identify the heterogeneity of patients with T2DM in short- and long-term glycemic status and prevalence of complications, providing recommendations for the timely adjustment in treatment regimes of patients with T2DM and promotion of personalized treatment.

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来源期刊
CiteScore
4.10
自引率
5.60%
发文量
72
审稿时长
3 months
期刊介绍: Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!
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