重症监护病房静脉对乙酰氨基酚输注时间对血压的影响。

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY International journal of clinical pharmacology and therapeutics Pub Date : 2023-07-01 DOI:10.5414/CP204360

Yasunori Urayama, Satoshi Kosaka, Tsugumi Ide, Mikio Shirota, Takeo Yasu

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引用次数: 0

摘要

目的:了解长时间静脉输注对乙酰氨基酚对血压的影响。材料和方法:我们回顾性研究了一组最初静脉注射对乙酰氨基酚的重症监护患者。我们使用倾向评分匹配来调整两组患者之间的差异:对照组(对乙酰氨基酚输注15分钟)和延长给药组(对乙酰氨基酚输注> 15分钟)。结果:对乙酰氨基酚给药后，对照组舒张压无变化，延长给药组舒张压在30、60分钟明显降低。结论:延长对乙酰氨基酚输注时间并不能阻止对乙酰氨基酚所致的血压降低。

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Effect of infusion time of intravenous acetaminophen on blood pressure in the intensive care unit.

Objective: To understand the effect of prolonged intravenous acetaminophen infusion on blood pressure.

Materials and methods: We retrospectively studied a cohort of intensive care patients receiving initial intravenous acetaminophen. We used propensity score matching to adjust for differences between patients who were classified into two groups: control (acetaminophen infusion for 15 minutes) and prolonged administration (acetaminophen infusion for > 15 minutes).

Results: After acetaminophen administration, diastolic blood pressure was unchanged in the control group, and was significantly lower at 30 and 60 minutes in the prolonged administration group.

Conclusion: Prolonged duration of acetaminophen infusion did not prevent acetaminophen-induced blood pressure reduction.

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来源期刊

International journal of clinical pharmacology and therapeutics 医学-药学

CiteScore

1.70

自引率

12.50%

发文量

116

审稿时长

4-8 weeks

期刊介绍： The International Journal of Clinical Pharmacology and Therapeutics appears monthly and publishes manuscripts containing original material with emphasis on the following topics: Clinical trials, Pharmacoepidemiology - Pharmacovigilance, Pharmacodynamics, Drug disposition and Pharmacokinetics, Quality assurance, Pharmacogenetics, Biotechnological drugs such as cytokines and recombinant antibiotics. Case reports on adverse reactions are also of interest.