Dong-Hee Kim, Bo-Ryoung Choi, In-Beom Jin, Jin-Ah Jeon, Sang-Pil Park, Jung-Soo Han
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Chemogenetic activation of lateral habenula accelerates the extinction of the appetitive conditioned responses.
A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation accelerated the decline in conditioned food-cup responses during extinction. The present results and the reports of previous LHb lesion studies suggest that LHb mediates appetitive extinction. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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