日本萎缩性胃炎和幽门螺杆菌感染流行趋势10年:2005 - 2015年ROAD研究

IF 1.4 Q4 ONCOLOGY Molecular and clinical oncology Pub Date : 2023-07-01 DOI:10.3892/mco.2023.2649
Izumi Inoue, Noriko Yoshimura, Toshiko Iidaka, Chiaki Horii, Shigeyuki Muraki, Hiroyuki Oka, Hiroshi Kawaguchi, Toru Akune, Takao Maekita, Kanae Mure, Kozo Nakamura, Sakae Tanaka, Masao Ichinose
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摘要

在日本,很少有大型基于人群的研究调查了萎缩性胃炎(AG)和幽门螺杆菌感染的患病率。本研究的目的是根据年龄估计AG和幽门螺杆菌感染的患病率,并使用基于大型人群队列的数据调查2005年至2016年日本AG和幽门螺杆菌感染的变化率。共有3596名参与者(基线调查(2005-2006)为1690名,第四次调查(2015-2016)为1906名),年龄在18至97岁之间。在基线和基于幽门螺杆菌抗体滴度和胃蛋白酶原水平的血清学测试的第四次调查中,检查了AG和幽门螺杆菌感染的患病率。AG和幽门螺杆菌感染率分别为40.1%(男性44.1%;女性,38.0%)和52.2%(男性,54.8%;女性,50.8%)。血清抗原阳性率在10年间从40.1下降到25.8%。10年间幽门螺杆菌血清阳性率由52.2%显著下降至35.5%。按年龄分层,AG患病率随年龄增长呈上升趋势,而幽门螺杆菌感染率随年龄增长呈上升趋势,除老年组外,呈倒u型关系。在这项以人群为基础、间隔10年的横断面研究中,AG和幽门螺杆菌感染的患病率显著下降。这种变化可能影响幽门螺杆菌相关疾病的患病率,包括与幽门螺杆菌引起的全身亚临床炎症和低氯酸血症相关的胃外疾病,如结肠直肠癌和动脉硬化。
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Trends in the prevalence of atrophic gastritis and Helicobacter pylori infection over a 10‑year period in Japan: The ROAD study 2005‑2015.

Few large population-based studies have examined the prevalence of atrophic gastritis (AG) and Helicobacter pylori infection in Japan. The purpose of the present study was to estimate the prevalence of AG and H. pylori infection by age, in addition to investigating their change rates from 2005 to 2016 in Japan using data from a large population-based cohort. A total of 3,596 participants [1,690 in the baseline survey (2005-2006) and 1,906 at the fourth survey (2015-2016)] aged 18 to 97 years were included in the cohort. The prevalence of AG and H. pylori infection were examined at baseline and in the fourth survey based on serological tests for the H. pylori antibody titer and pepsinogen levels. The prevalence of AG and H. pylori infection were 40.1% (men, 44.1%; women, 38.0%) and 52.2% (men, 54.8%; women, 50.8%), respectively, at baseline. AG seropositivity rates showed a significant decrease from 40.1 to 25.8% in 10 years. H. pylori seropositivity rates decreased significantly from 52.2 to 35.5% in 10 years. Stratified for age, the prevalence of AG showed an increasing trend with age, whereas the prevalence of H. pylori infection increased with aging, except for in the elderly group, showing an inverted U-shaped association. In this population-based, cross-sectional study with a 10-year interval survey, the prevalence of AG and H. pylori infection decreased significantly. This change may influence the prevalence of H. pylori-related diseases, including extra-gastric disorders associated with H. pylori-induced systemic subclinical inflammation and hypochlorhydria, such as colorectal neoplasia and arteriosclerosis.

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