局部麻醉和免疫疗法:对抗癌症的新组合。

IF 7.9 2区 医学 Q1 IMMUNOLOGY Seminars in Immunopathology Pub Date : 2023-03-01 DOI:10.1007/s00281-022-00960-6
Lucillia Bezu, Oliver Kepp, Guido Kroemer
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引用次数: 3

摘要

肿瘤内注射溶瘤剂(如改良单纯疱疹病毒T-VEC)或局部给予非病毒性溶瘤治疗(如射频、化疗栓塞、冷冻消融或放疗)可激活抗癌免疫反应,从而触发体外效应,减少继发性病变。初步数据表明,溶瘤治疗可调节肿瘤浸润免疫效应,并可与免疫检查点抑制剂有利地联合使用。最近的研究结果表明,局部麻醉剂通常用于控制手术疼痛,如果注射到恶性病变处,也具有类似溶瘤治疗的抗肿瘤作用。此外,在几种临床前肿瘤模型中,局麻药与全身免疫检查点抑制的关联显著提高了总生存率。这可能是由局部麻醉剂的直接细胞毒活性和额外的免疫相关的体外作用来解释的。我们还总结了局部麻醉和免疫治疗联合应用提高免疫系统对肿瘤控制的分子和细胞机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Local anesthetics and immunotherapy: a novel combination to fight cancer.

Intratumoral injection of oncolytic agents such as modified herpes simplex virus T-VEC or local administration of non-viral oncolytic therapies (such as radiofrequency, chemoembolization, cryoablation, or radiotherapy) can activate an anticancer immune response and hence trigger abscopal effects reducing secondary lesions. Preliminary data suggested that oncolytic treatments modulate tumor-infiltrating immune effectors and can be advantageously combined with the immune checkpoint inhibitors. Recent findings indicate that local anesthetics, which are usually used in the clinics to control surgical pain, also possess antineoplastic effects mimicking oncolytic treatments if they are injected into malignant lesions. Moreover, the association of local anesthetics with systemic immune checkpoint inhibition significantly improved overall survival in several preclinical tumor models. This may be explained by direct cytotoxic activity of local anesthetics and additional immune-related abscopal effects. We also summarize the molecular and cellular mechanisms by which the combination of local anesthetics and immunotherapy improves tumor control by the immune system.

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来源期刊
Seminars in Immunopathology
Seminars in Immunopathology 医学-病理学
CiteScore
19.80
自引率
2.20%
发文量
69
审稿时长
12 months
期刊介绍: The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.
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