治疗性血浆交换治疗对重症COVID-19 ARDS患者静脉-静脉ECMO脱机成功率的影响

IF 1.5 4区医学 Q3 HEMATOLOGY Therapeutic Apheresis and Dialysis Pub Date : 2023-08-01 DOI:10.1111/1744-9987.13979

Murat Aslan, Rabia Yılmaz, Murat Doğan, Zafer Çukurova

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引用次数: 0

摘要

本研究旨在探讨TPE(治疗性血浆置换)治疗对V-V ECMO治疗的重症COVID-19 ARDS患者ECMO成功脱机的影响。方法:回顾性分析2020年1月1日至2022年3月1日在ICU住院的18岁以上患者。结果:研究共纳入33例患者，其中36.3% (n: 12)的患者接受了TPE治疗。TPE治疗组ECMO脱机成功率高于无TPE组(14.3% [n: 3]， TPE组:50% [n: 6]， p = 0.044)。TPE治疗组的1个月死亡率也有统计学意义(p = 0.044)。在logistic分析中发现，未接受TPE治疗的患者(OR;6.0, 95% ci;1.134-31.735, p = 0.035)。结论:TPE治疗可提高V-V ECMO治疗的重症COVID-19 ARDS患者V-V ECMO脱机成功率。

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The effect of therapeutic plasma exchange therapy on veno-venous ECMO weaning success in severe COVID-19 ARDS patients.

Introduction: Primarily, this study aimed to investigate the effect of TPE (therapeutic plasma exchange) treatment on successful ECMO weaning in severe COVID-19 ARDS patients treated with V-V ECMO.

Methods: The study was applied retrospectively on patients over the age of 18 who were hospitalized in the ICU between January 1, 2020 and March 1, 2022.

Results: The study was performed on 33 patients, 36.3% (n: 12) of whom received TPE treatment. The rate of successful ECMO weaning was statistically higher in the TPE treatment group (without TPE: 14.3% [n: 3], with TPE: 50% [n: 6], p = 0.044). The 1-month mortality was also statistically lower in the TPE treatment group (p = 0.044). In the logistic analysis, It was found that the risk of unsuccessful ECMO weaning increased 6 times in those who did not receive TPE treatment (OR; 6.0, 95% CI; 1.134-31.735, p = 0.035).

Conclusion: TPE treatment may increase the success rate of V-V ECMO weaning in severe COVID-19 ARDS patients treated with V-V ECMO.

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.