原发性免疫缺陷(PID)的自身免疫。

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2023-08-01 DOI:10.1007/s12016-022-08942-0
Grace T Padron, Vivian P Hernandez-Trujillo
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引用次数: 3

摘要

原发性免疫缺陷(PID)可能影响免疫系统的任何组成部分。随着基因检测方法的进步,PID和免疫失调疾病的数量正在稳步增长。这些广泛的识别方法已经改变了我们描述PID的方式。虽然PID曾经以其对感染的易感性为特征,但遗传分析的增加已经阐明了PID与非感染性表现(包括自身免疫)之间的相互交织关系。允许机会性感染的缺陷也可能导致自身免疫性疾病的发展。在某些情况下,非感染性并发症可能是PID自身免疫性疾病的表现,如自身免疫性细胞减少症、肠病、内分泌病和关节炎等,在PID中已被报道。虽然任何PID都可能发生自身免疫,但本综述将着眼于某些与自身免疫最相关的免疫缺陷,以及它们的诊断和管理策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Autoimmunity in Primary Immunodeficiencies (PID).

Primary immunodeficiency (PID) may impact any component of the immune system. The number of PID and immune dysregulation disorders is growing steadily with advancing genetic detection methods. These expansive recognition methods have changed the way we characterize PID. While PID were once characterized by their susceptibility to infection, the increase in genetic analysis has elucidated the intertwined relationship between PID and non-infectious manifestations including autoimmunity. The defects permitting opportunistic infections to take hold may also lead the way to the development of autoimmune disease. In some cases, it is the non-infectious complications that may be the presenting sign of PID autoimmune diseases, such as autoimmune cytopenia, enteropathy, endocrinopathies, and arthritis among others, have been reported in PID. While autoimmunity may occur with any PID, this review will look at certain immunodeficiencies most often associated with autoimmunity, as well as their diagnosis and management strategies.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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