Akwesasne Mohawk 妇女接触多氯联苯和六氯苯与血清中甲状腺过氧化物酶自身抗体水平升高有关。

IF 2.3 4区 医学 Q3 ENVIRONMENTAL SCIENCES Journal of Toxicology and Environmental Health-Part A-Current Issues Pub Date : 2023-09-02 Epub Date: 2023-06-19 DOI:10.1080/15287394.2023.2226685
Florence Lee, Mia V Gallo, Lawrence M Schell, Julia Jennings, David A Lawrence, Akwesasne Task Force On The Environment
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引用次数: 0

摘要

据报道,包括多氯联苯(PCB)、六氯苯(HCB)和二氯二苯三氯乙烷(p,p'-DDT)在内的持久性有机污染物(POPs)会影响免疫活动。作为干扰内分泌的化学品 (EDC),这些污染物可能会破坏正常的甲状腺功能,并通过直接或间接影响甲状腺过氧化物酶抗体 (TPOAbs) 的水平,成为自身免疫性甲状腺疾病的催化剂。美国原住民社区接触有害有毒物质的比例过高,患自身免疫性疾病的风险也随之增加。本研究旨在确定美国原住民妇女血清中持久性有机污染物与 TPOAbs 之间的关联。这项评估用于衡量自身免疫性甲状腺疾病的风险是否因接触持久性有机污染物而增加。研究人员在 2009 年至 2013 年期间收集了 183 名年龄在 21-38 岁之间的 Akwesasne Mohawk 妇女的数据。我们进行了多变量分析,以确定有毒物质暴露与 TPOAbs 水平之间的关联。在多重逻辑回归分析中,接触多氯联苯同系物 33 与 TPOAbs 超过正常水平的风险升高有关。此外,与 TPOAb 水平正常的女性相比,接触六氯代苯导致 TPOAb 水平高于正常水平的风险高出 2 倍以上。接触多氯联苯同系物 33 和六氯代苯与 TPOAb 水平高于正常值有关,而 TPOAb 是自身免疫性甲状腺疾病的标志物。要确定自身免疫性甲状腺疾病的病因和相关因素,还需要进行更多的调查,因为这种疾病的病因是多方面的,而且十分复杂。
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Exposure of Akwesasne Mohawk women to polychlorinated biphenyls and hexachlorobenzene is associated with increased serum levels of thyroid peroxidase autoantibodies.

Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and dichlorodiphenyltrichloroethane (p,p'-DDT) were reported to influence immunological activity. As endocrine-disrupting chemicals (EDC), these pollutants may disrupt normal thyroid function and act as catalysts for development of autoimmune thyroid disease by directly and indirectly affecting levels of thyroid peroxidase antibodies (TPOAbs). Native American communities are disproportionately exposed to harmful toxicants and are at an increased risk of developing an autoimmune disease. The aim of this study was to determine the association between POPs and TPOAbs in serum obtained from Native American women. This assessment was used to measure whether increased risk of autoimmune thyroid disease occurred as a result of exposure to POPs. Data were collected from 183 Akwesasne Mohawk women, 21-38 years of age, between 2009 and 2013. Multivariate analyses were conducted to determine the association between toxicant exposure and levels of TPOAbs. In multiple logistic regression analyses, exposure to PCB congener 33 was related to elevated risk of individuals possessing above normal levels of TPOAbs. Further, HCB was associated with more than 2-fold higher risk of possessing above normal levels of TPOAbs compared to women with normal levels of TPOAbs. p,p'-DDE was not associated with TPOAb levels within this study. Exposure to PCB congener 33 and HCB was correlated with above normal levels of TPOAbs, a marker of autoimmune thyroid disease. Additional investigations are needed to establish the causes and factors surrounding autoimmune thyroid disease which are multiple and complex.

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来源期刊
CiteScore
5.20
自引率
19.20%
发文量
46
审稿时长
8-16 weeks
期刊介绍: The Journal of Toxicology and Environmental Health, Part A , Current Issues is an authoritative journal that features strictly refereed original research in the field of environmental sciences, public and occupational health, and toxicology.
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