击中目标:mRNA和生物分子凝聚物在健康和疾病中的定位。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-11-01 Epub Date: 2023-07-02 DOI:10.1002/wrna.1807
Jessica P Otis, Kimberly L Mowry
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引用次数: 0

摘要

亚细胞mRNA定位对许多生物过程至关重要,如细胞极性发育、胚胎发生、组织分化、蛋白质复合物形成、细胞迁移、对环境刺激和突触去极化的快速反应。我们对mRNA定位机制的理解现在必须修正,以包括生物分子凝聚体的形成和运输,因为最近发现了几种运输和定位mRNA的生物分子凝聚体。mRNA定位的中断可能对发育过程和生物分子凝聚生物学产生灾难性影响,并已被证明与多种疾病有关。对mRNA定位的基本理解对于理解这种生物学异常如何通过支持癌细胞迁移和生物分子凝聚失调来促进许多癌症的病因至关重要,以及通过mRNA定位和生物分子凝聚生物学的失调来促进许多神经退行性疾病。本文分类为:RNA输出和定位> RNA定位RNA在疾病和发展> RNA在疾病RNA在疾病和发展> RNA在发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Hitting the mark: Localization of mRNA and biomolecular condensates in health and disease.

Subcellular mRNA localization is critical to a multitude of biological processes such as development of cellular polarity, embryogenesis, tissue differentiation, protein complex formation, cell migration, and rapid responses to environmental stimuli and synaptic depolarization. Our understanding of the mechanisms of mRNA localization must now be revised to include formation and trafficking of biomolecular condensates, as several biomolecular condensates that transport and localize mRNA have recently been discovered. Disruptions in mRNA localization can have catastrophic effects on developmental processes and biomolecular condensate biology and have been shown to contribute to diverse diseases. A fundamental understanding of mRNA localization is essential to understanding how aberrations in this biology contribute the etiology of numerous cancers though support of cancer cell migration and biomolecular condensate dysregulation, as well as many neurodegenerative diseases, through misregulation of mRNA localization and biomolecular condensate biology. This article is categorized under: RNA Export and Localization > RNA Localization RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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