秀丽隐杆线虫与年龄相关的解剖和生理改变

IF 5.3 3区医学 Q2 CELL BIOLOGY Mechanisms of Ageing and Development Pub Date : 2023-07-01 DOI:10.1016/j.mad.2023.111827

Emmanuel Spanoudakis , Nektarios Tavernarakis

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引用次数: 1

摘要

自从Sydney Brenner引入秀丽隐杆线虫以来，它已经成为一种被广泛研究的生物。鉴于其高度重要的特性，包括透明度、寿命短、自我受精、高繁殖产量以及易于操作和基因修饰，该线虫有助于阐明生物学的几个基本方面，如发育和衰老。此外，它已被广泛用作与衰老相关的人类疾病建模的平台，尤其是与神经退行性变相关的疾病。将秀丽隐杆线虫用于此类目的需要并同时促进对其正常衰老过程的研究。在这篇综述中，我们的目的是从形态和功能方面总结蠕虫正常衰老过程中的主要组织变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Age-associated anatomical and physiological alterations in Caenorhabditis elegans

Since its introduction by Sydney Brenner, Caenorhabditis elegans has become a widely studied organism. Given its highly significant properties, including transparency, short lifespan, self-fertilization, high reproductive yield and ease in manipulation and genetic modifications, the nematode has contributed to the elucidation of several fundamental aspects of biology, such as development and ageing. Moreover, it has been extensively used as a platform for the modelling of ageing-associated human disorders, especially those related to neurodegeneration. The use of C. elegans for such purposes requires, and at the same time promotes the investigation of its normal ageing process. In this review we aim to summarize the major organismal alterations during normal worm ageing, in terms of morphology and functionality.

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.