肾癌耐药的机制和临床意义:免疫检查点抑制剂的叙述性回顾。

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2023-01-01 DOI:10.20517/cdr.2023.02
Sunil Samnani, Faraz Sachedina, Mehul Gupta, Edward Guo, Vishal Navani
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引用次数: 0

摘要

透明细胞肾细胞癌(ccRCC)是肾细胞癌最常见的组织学亚型。近年来,随着抗程序性死亡-1 (PD-1)主干的联合治疗,ccRCC患者的预后有所改善。这提高了该病患者的生活质量和预期寿命。不幸的是,并非所有患者都能受益;最终,大多数患者会对治疗产生耐药性并取得进展。最近的分子、生化和免疫学研究广泛地研究了抗血管生成和免疫治疗的耐药机制。该分析概述了与免疫检查点抑制剂(ICIs)相关的耐药途径的基本原理。此外,本文还讨论了在试验环境中可能考虑的克服耐药性的新方法。
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Mechanisms and clinical implications in renal carcinoma resistance: narrative review of immune checkpoint inhibitors.

Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cell carcinoma. The prognosis for patients with ccRCC has improved over recent years with the use of combination therapies with an anti-programmed death-1 (PD-1) backbone. This has enhanced the quality of life and life expectancy of patients with this disease. Unfortunately, not all patients benefit; eventually, most patients will develop resistance to therapy and progress. Recent molecular, biochemical, and immunological research has extensively researched anti-angiogenic and immune-based treatment resistance mechanisms. This analysis offers an overview of the principles underpinning the resistance pathways related to immune checkpoint inhibitors (ICIs). Additionally, novel approaches to overcome resistance that may be considered for the trial context are discussed.

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