重塑肿瘤微环境克服hpv阴性头颈癌的治疗耐药。

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2023-01-01 DOI:10.20517/cdr.2022.141
Sergi Benavente
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引用次数: 1

摘要

尽管付出了巨大的努力和完善的技术,hpv阴性头颈癌的总体生存率仍然很低。在免疫冷淡和排除的肿瘤如hpv阴性头颈癌中,需要强大的免疫启动来引发强烈和持久的抗肿瘤免疫反应。本文重点介绍了不同类型的免疫细胞和基质细胞如何影响肿瘤微环境,权衡了将肿瘤微环境的代谢调节纳入癌症治疗策略的必要性,并总结了个性化免疫治疗策略在hpv阴性头颈癌中的临床适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer.

Despite intensive efforts and refined techniques, overall survival in HPV-negative head and neck cancer remains poor. Robust immune priming is required to elicit a strong and durable antitumor immune response in immunologically cold and excluded tumors like HPV-negative head and neck cancer. This review highlights how the tumor microenvironment could be affected by different immune and stromal cell types, weighs the need to integrate metabolic regulation of the tumor microenvironment into cancer treatment strategies and summarizes the emerging clinical applicability of personalized immunotherapeutic strategies in HPV-negative head and neck cancer.

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