对百日咳的有效性DTaP≤2岁的孩子——临沂,山东,中国,2017 - 2019。

Pinpin Zhu, Dan Wu, Yan Wang, Xiaoxue Liu, Lance E Rodewald, Yixing Li, Hui Zheng, Lei Cao, Yifan Song, Li Song, Xiaodong Zhao, Jianyi Yao, Fuzhen Wang, Mingshuang Li, Qian Zhang, Tingting Yan, Zundong Yin
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摘要

关于这个话题我们已经知道了什么?疫苗有效性(VE)与联合纯化白喉、破伤风和无细胞百日咳疫苗(DTaP)的接种次数呈正相关。在中山市开展的一项配对病例对照研究显示,4-11月龄儿童共纯化DTaP - VE对百日咳相关疾病的防治效果,一剂为42%,两剂为88%,三剂为95%。这份报告增加了什么内容?本研究的结果有助于目前的研究。我们发现共纯化DTaP对百日咳相关疾病和住院治疗的VE显著增加,从一次剂量后的24%-26%到四次剂量后的86%-87%。这对公共卫生实践有什么影响?本研究结果强调了及时和全面使用共纯化DTaP免疫对降低百日咳发病率的意义。此外,这些发现为支持修改中国百日咳疫苗接种方法提供了证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Effectiveness of DTaP Against Pertussis in ≤2-Year-Old Children - Linyi Prefecture, Shandong Province, China, 2017-2019.

What is already known about this topic?: Vaccine effectiveness (VE) is positively correlated with the number of administered co-purified diphtheria, tetanus, and acellular pertussis vaccine (DTaP) doses. A matched case-control study conducted in Zhongshan City revealed that the co-purified DTaP VE against pertussis-related illnesses in children aged 4-11 months was 42% for one dose, 88% for two doses, and 95% for three doses, respectively.

What is added by this report?: The results of this study contribute to the current body of research. We found that the VE of co-purified DTaP against pertussis-related illness and hospitalization increased substantially, ranging from 24%-26% after one dose to 86%-87% after four doses.

What are the implications for public health practice?: The results of this study underscore the significance of prompt and comprehensive immunization using co-purified DTaP to decrease the incidence of pertussis. Additionally, these findings offer evidence supporting the modification of China's pertussis vaccination approach.

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