EGFR、e -钙粘蛋白和PTP1B在表皮稳态中的相互作用。

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Tissue Barriers Pub Date : 2023-07-03 DOI:10.1080/21688370.2022.2104085

Tessa Arnaud, Fernando Rodrigues-Lima, Mireille Viguier, Frédérique Deshayes

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引用次数: 1

摘要

维持上皮内稳态是胚胎发育的关键，也是由表皮保证的保护屏障。这种体内平衡是通过几种分子的表达来调节的，其中EGFR和e -钙粘蛋白是非常重要的。事实上，这些蛋白调控的缺陷会导致细胞粘附、增殖、分化和迁移的异常。因此，这两种蛋白的调控是至关重要的，因为它们与许多皮肤疾病和癌症有关。在过去的几十年里，已经描述了这两种蛋白质的几种调节途径，特别是这些伙伴之间交叉调节的几种机制。在这篇综述中，我们旨在描述目前对EGFR调控和EGFR与e -钙粘蛋白之间相互作用的理解，特别是这些交叉调控在上皮稳态中的意义。我们特别关注PTP1B，一种参与EGFR调节的磷酸酶。

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Interplay between EGFR, E-cadherin, and PTP1B in epidermal homeostasis.

Maintaining epithelial homeostasis is crucial to allow embryo development but also the protective barrier which is ensured by the epidermis. This homeostasis is regulated through the expression of several molecules among which EGFR and E-cadherin which are of major importance. Indeed, defects in the regulation of these proteins lead to abnormalities in cell adhesion, proliferation, differentiation, and migration. Hence, regulation of these two proteins is of the utmost importance as they are involved in numerous skin pathologies and cancers. In the last decades it has been described several pathways of regulation of these two proteins and notably several mechanisms of cross-regulation between these partners. In this review, we aimed to describe the current understanding of the regulation of EGFR and interactions between EGFR and E-cadherin and, in particular, the implication of these cross-regulations in epithelium homeostasis. We pay particular attention to PTP1B, a phosphatase involved in the regulation of EGFR.

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来源期刊

Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.60

自引率

6.50%

发文量

期刊介绍： Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.